William J. Nathan

National Human Genome Research Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index747citations11works4.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

DNA Repair Mechanisms(7), Genomics and Chromatin Dynamics(5), CRISPR and Genetic Engineering(2), Genetics and Neurodevelopmental Disorders(2), PARP inhibition in cancer therapy(2)

Publications11 total

Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders
2025· 6 cited
Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease
2024· 2 citedOpen Access
Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence
Molecular Cell·2023· 57 citedOpen Access
Active DNA demethylation promotes cell fate specification and the DNA damage response
Science·2022· 98 citedOpen Access
S1-END-seq reveals DNA secondary structures in human cells
Molecular Cell·2022· 61 citedOpen Access
Linking Dynamic DNA Secondary Structures to Genome Instability
2022· 3 citedOpen Access
The WRN helicase: resolving a new target in microsatellite unstable cancers
Current Opinion in Genetics & Development·2021· 28 cited
Neuronal enhancers are hotspots for DNA single-strand break repair
Nature·2021· 223 citedOpen Access
Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair
2020· 19 citedOpen Access
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
Nature·2020· 182 citedOpen Access
Prolonged Pneumococcal Meningitis Due to an Organism With Increased Resistance to Penicillin
PEDIATRICS·1976· 68 cited

Frequent Co-authors

André Nussenzweig(8), Wei Wu(6), Elsa Callén(5), Niek van Wietmarschen(5), Raphael Pavani(4), Peter J. McHugh(4), Dongpeng Wang(3), Keith W. Caldecott(3), Michael E. Ward(3), Frida Belinky(3), Veenu Tripathi(3), Karen Usdin(3), Gabriel Matos‐Rodrigues(3), Sarah E. Hill(2), Jacob Paiano(2), Kenta Shinoda(2), J Colon(2), Dali Zong(2), Raffaella De Pace(2), Han‐Yu Shih(2)