Stephen Schmidt

Harvard University — United States

Medicine · Health Sciences

19h-index1.4kcitations40works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Lung Cancer Treatments and Mutations(10), PI3K/AKT/mTOR signaling in cancer(8), Chronic Lymphocytic Leukemia Research(4), Immune cells in cancer(4), Cancer therapeutics and mechanisms(4)

Publications40 total

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
Journal of Medicinal Chemistry·2022· 119 citedOpen Access
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis
Nature Immunology·2022· 1 citedOpen Access
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis
Nature Immunology·2022· 87 citedOpen Access
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
Nature Cardiovascular Research·2021· 80 citedOpen Access
RTK-dependent inducible degradation of mutant PI3Kα drives GDC-0077 (Inavolisib) efficacy
2021· 5 citedOpen Access
Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity
Journal of Medicinal Chemistry·2021· 25 citedOpen Access
Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche
Nature Biomedical Engineering·2020· 119 citedOpen Access
Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor <sup>64</sup> Cu-Macrin in Mice, Rabbits, and Pigs
Circulation Cardiovascular Imaging·2020· 42 citedOpen Access
Abstract PR03: Selective degradation of mutant PIK3CA promotes increased mutant specificity in a subset of PI3K ATP-competitive inhibitors
Molecular Cancer Research·2020
Fluorescence microscopy tensor imaging representations for large-scale dataset analysis
Scientific Reports·2020· 9 citedOpen Access
Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction
Journal of the American College of Cardiology·2020· 37 citedOpen Access
Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs
PLoS ONE·2019· 17 citedOpen Access
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
Utrecht University Repository (Utrecht University)·2019
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
Nature Medicine·2019· 262 citedOpen Access
Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases
Neuro-Oncology·2019· 95 citedOpen Access
A mouse model of recurrent myocardial infarction reports diminished emergency hematopoiesis and cardiac inflammation
2019· 1 citedOpen Access
The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in <i>PIK3CA</i> -Mutant Breast Cancer Brain Metastases
Clinical Cancer Research·2019· 82 citedOpen Access
Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics
Drug Metabolism and Pharmacokinetics·2019
Genotype-targeted local therapy of glioma
Proceedings of the National Academy of Sciences·2018· 53 citedOpen Access
Abstract 156: Preclinical characterization of GDC-0077, a specific PI3K alpha inhibitor in early clinical development
Cancer Research·2017· 14 cited
page 1 of 2Next →

Frequent Co-authors

Gregory R. Wojtkiewicz(13), Emily J. Hanan(12), Shiva Malek(11), Matthias Nahrendorf(10), Steve Sideris(10), David Rohde(9), Filip K. Świrski(9), Ivana Yen(9), Maximilian J. Schloss(8), Lori S. Friedman(8), Hans E. Purkey(8), Timothy P. Heffron(8), Gabriel Courties(7), Yoshiko Iwamoto(7), Charles Eigenbrot(7), Gabriele Schaefer(7), Vanessa Frodermann(6), Sebastian Cremer(6), Shuang Zhang(6), Robert A. Heald(6)