Diana L. Donnelly‐Roberts

AbbVie (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index6.1kcitations113works9.52yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(51), Receptor Mechanisms and Signaling(28), Cholinesterase and Neurodegenerative Diseases(21), Adenosine and Purinergic Signaling(20), Ion channel regulation and function(16)

Publications113 total

Development of eIF2B Activator ABBV-CLS-7262 as a Novel Treatment for Vanishing White Matter Disease (P2-8.001)
Neurology·2024
GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system
CNS Neuroscience & Therapeutics·2024· 19 citedOpen Access
GDF15 is a dynamic biomarker of the Integrated Stress Response in the central nervous system
2023· 1 citedOpen Access
474 IL-25 induces skin inflammation in mice: Effects of a selective JAK inhibitor
Journal of Investigative Dermatology·2021
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design
Journal of Medicinal Chemistry·2020· 41 citedOpen Access
NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation
Journal of Translational Autoimmunity·2020· 11 citedOpen Access
Small Molecule Phenotypic Screen Identifies Novel Regulators of LDLR Expression
ACS Chemical Biology·2020· 3 cited
Characterization of psoriasiform dermatitis induced by systemic injection of interleukin‐23 minicircles in mice
The Journal of Dermatology·2019· 16 cited
Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses
ACS Chemical Biology·2019· 21 cited
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
eLife·2019· 214 citedOpen Access
Author response: eIF2B activator prevents neurological defects caused by a chronic integrated stress response
2018Open Access
eIF2B activator prevents neurological defects caused by a chronic Integrated Stress Response
2018· 18 citedOpen Access
Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats
Journal of Pharmacological and Toxicological Methods·2018· 20 cited
Losartan improves renal function and pathology in obese ZSF-1 rats
Journal of Basic and Clinical Physiology and Pharmacology·2018· 13 cited
IL-23 mediated skin inflammation is dependent on the expansion and function of RORγt expressing cells
The Journal of Immunology·2017· 1 cited
667 Characterization and pharmacological modulation of dermatitis induced by injection of IL-23 minicircles in mice
Journal of Investigative Dermatology·2017Open Access
PowerPoint Slides for: Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy
Figshare·2016Open Access
Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy
American Journal of Nephrology·2016· 44 citedOpen Access
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Pharmacological Reviews·2015· 138 cited
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists
Biochemical Pharmacology·2015· 14 cited
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Frequent Co-authors

James P. Sullivan(21), Stephen P. Arnerić(18), Marian T. Namovic(17), Michael F. Jarvis(13), Jorge D. Brioni(13), Michael Decker(12), Mark W. Holladay(12), David J. Anderson(11), Prisca Honoré(8), Kennan C. Marsh(8), Clark A. Briggs(8), Anthony W. Bannon(7), Nan‐Horng Lin(7), William A. Carroll(7), Jeffrey E. Campbell(7), Murali Gopalakrishnan(7), Marietta Piattoni-Kaplan(7), Robert B. Moreland(7), Gin C. Hsieh(6), Connie R. Faltynek(6)