Matthias Gstaiger

ETH Zurich — Switzerland

Chemistry · Physical Sciences

46h-index10.2kcitations107works5.62yr avg
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Research Topics

Advanced Proteomics Techniques and Applications(32), Bioinformatics and Genomic Networks(14), Ubiquitin and proteasome pathways(13), Mass Spectrometry Techniques and Applications(9), Enzyme Structure and Function(8)

Publications107 total

Allosteric Gain-of-Function and Off-Mechanism Effects of ATP-Competitive Kinase Inhibitors Revealed by Multimodal Proteomics
2025Open Access
Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies
2025· 1 citedOpen Access
Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes
Nature Biotechnology·2025· 14 citedOpen Access
Covalent targeting leads to the development of LIMK1 isoform-selective inhibitors
2025Open Access
Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL–ML Hit
RSC Chemical Biology·2025· 2 citedOpen Access
Toward target 2035: EUbOPEN - a public–private partnership to enable & unlock biology in the open
UNC Libraries·2024Open Access
Toward target 2035: EUbOPEN - a public–private partnership to enable & unlock biology in the open
RSC Medicinal Chemistry·2024· 3 citedOpen Access
Author response for "Rapid, Potent, and Persistent Covalent Chemical Probes to Deconvolute PI3Kα Signaling"
2024
A chemical probe to modulate human GID4 Pro/N-degron interactions
Nature Chemical Biology·2024· 20 cited
An atlas of protein-protein associations of human tissues prioritizes candidate disease genes
2024· 5 citedOpen Access
DIP-MS: ultra-deep interaction proteomics for the deconvolution of protein complexes
Nature Methods·2024· 21 citedOpen Access
Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling
Chemical Science·2024· 5 citedOpen Access
Harnessing CD3 diversity to optimize CAR T cells
Nature Immunology·2023· 61 citedOpen Access
DIP-MS: A novel ultra-deep interaction proteomics for the deconvolution of protein complexes
2023· 1 citedOpen Access
Phosphorylation‐linked complex profiling identifies assemblies required for Hippo signal integration
Molecular Systems Biology·2023· 16 citedOpen Access
Target Deconvolution by Limited Proteolysis Coupled to Mass Spectrometry
Methods in molecular biology·2023· 16 cited
Harnessing CD3 diversity to optimise CAR T cells
Research Square (Research Square)·2022Open Access
Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics
Proceedings of the National Academy of Sciences·2022· 16 citedOpen Access
Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα
Journal of the American Chemical Society·2022· 51 citedOpen Access
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Frequent Co-authors

Ruedi Aebersold(26), Timo Glatter(8), Alexander Wepf(8), Audrey van Drogen(8), Simon Hauri(7), Markku Varjosalo(7), Wilhelm Krek(6), Ben C. Collins(5), George Rosenberger(5), Oliver Rinner(5), Nicolas Tapon(4), Moritz Heusel(4), Isabell Bludau(4), Fabian Frommelt(4), Giulio Superti‐Furga(3), Anne‐Claude Gingras(3), Anton Vichalkovski(3), Oleg Georgiev(3), Walter Schaffner(3), C Wirbelauer(3)