David A. Dichek

University of Washington — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index7.1kcitations166works2.32yr avg
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Research Topics

Protease and Inhibitor Mechanisms(41), Virus-based gene therapy research(36), RNA Interference and Gene Delivery(23), Blood Coagulation and Thrombosis Mechanisms(23), Cell Adhesion Molecules Research(18)

Publications166 total

Single cell analysis identifies a distinct population of fibroblasts that mediate increased cell-cell communication in murine aortopathy of Loeys-Dietz syndrome
Journal of Molecular and Cellular Cardiology·2025
Overexpression of ABCA1 in Carotid Endothelium of Hyperlipidemic Rabbits Modulates Vascular Inflammation
Human Gene Therapy·2025· 3 cited
Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models
Arteriosclerosis Thrombosis and Vascular Biology·2025· 3 citedOpen Access
Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice
Arteriosclerosis Thrombosis and Vascular Biology·2025· 8 citedOpen Access
Exosome-Mediated Transfer of X-Motif-Tagged Anti-MiR-33a-5p Antagomirs to the Medial Cells of Transduced Rabbit Carotid Arteries
Biology·2024Open Access
Abstract 3079: Overexpression Of Abca1 In Carotid Endothelium Of Hyperlipidemic Rabbits Decreases Vascular Inflammation
Arteriosclerosis Thrombosis and Vascular Biology·2024
Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies
Arteriosclerosis Thrombosis and Vascular Biology·2023· 47 citedOpen Access
Subclinical Atherosclerosis: Part 1: What Is it? Can it Be Defined at the Histological Level?
Arteriosclerosis Thrombosis and Vascular Biology·2023· 43 citedOpen Access
Apolipoprotein A-I vascular gene therapy reduces vein-graft atherosclerosis
Molecular Therapy — Methods & Clinical Development·2023· 2 citedOpen Access
N-terminal eGFP-tagging of rabbit apolipoprotein A-I decreases expression and impairs cholesterol-efflux activity
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2023Open Access
Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases
Atherosclerosis·2022· 39 citedOpen Access
Novel expression cassettes for increasing apolipoprotein AI transgene expression in vascular endothelial cells
Scientific Reports·2022· 1 citedOpen Access
Novel expression cassettes for increasing apolipoprotein AI transgene expression in vascular endothelial cells
Research Square (Research Square)·2022Open Access
Novel expression cassettes for increasing apolipoprotein AI transgene expression in vascular endothelial cells
2022Open Access
Abstract 357: Expression of a Constitutively Active TGF-β Receptor-1 in Mouse Aortic Smooth Muscle Cells Does Not Cause Severe Aortopathy
Arteriosclerosis Thrombosis and Vascular Biology·2022
Abstract 430: GFP-tagging Of Rabbit ApoAI Decreases Expression And Cholesterol-efflux Activity
Arteriosclerosis Thrombosis and Vascular Biology·2022
Abstract 444: Apolipoprotein A-I (ApoAI) Vascular Gene Therapy Protects Against Vein-Graft Atherosclerosis
Arteriosclerosis Thrombosis and Vascular Biology·2022
Abstract 482: Early Reduction of Blood Flow in Rabbit Jugular Vein-Carotid Artery Bypass Grafts is not Caused by Anastomotic Stenosis
Arteriosclerosis Thrombosis and Vascular Biology·2022
Abstract 544: Single-Cell RNA Sequencing Suggests Roles For Cell-Matrix Interactions And Inflammation In The Pathogenesis Of Aortopathy In Loeys-Dietz Syndrome
Arteriosclerosis Thrombosis and Vascular Biology·2022
Blockade of TGF-β (Transforming Growth Factor Beta) Signaling by Deletion of <i>Tgfbr2</i> in Smooth Muscle Cells of 11-Month-Old Mice Alters Aortic Structure and Causes Vasomotor Dysfunction—Brief Report
Arteriosclerosis Thrombosis and Vascular Biology·2022· 9 citedOpen Access
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Frequent Co-authors

Renu Virmani(14), Kurt D. Newman(8), Andrew H. Schulick(7), Mary Beth DeYoung(6), Jie Hu(5), Andrew D. Frutkin(4), Wei Hao(4), Liang Du(4), Shan Wen(4), Darren B. Schneider(3), S.W. Lee(3), Jeffrey J. Rade(3), Jonathan J. Rome(3), Vafa Shayani(3), Robert Driscoll(3), Giuseppe Vassalli(3), Stoyan N. Angelov(3), Michal Kremen(3), Goro Otsuka(3), Mia Jaffe(3)