Toshifumi Morimura

Shiga University of Medical Science — Japan

Medicine · Health Sciences

21h-index3.5kcitations44works0.02yr avg
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Research Topics

Herpesvirus Infections and Treatments(9), Neurogenesis and neuroplasticity mechanisms(7), Cytomegalovirus and herpesvirus research(7), Amyotrophic Lateral Sclerosis Research(6), Neurogenetic and Muscular Disorders Research(4)

Publications44 total

Structure and thickness of Glisson's capsule differ considerably on the liver surface in mammalian species
The Anatomical Record·2025
Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation
2023· 1 citedOpen Access
In vivo analysis of aggregation propensity of low levels of mislocalized TDP-43 on cytopathological and behavioral phenotype of ALS/FTLD
Neuroscience Research·2023· 2 citedOpen Access
Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates
Scientific Reports·2022· 10 citedOpen Access
Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro
Communications Biology·2022· 43 citedOpen Access
Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis
International Journal of Molecular Sciences·2020· 7 citedOpen Access
Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein
Journal of Alzheimer s Disease·2020· 32 citedOpen Access
Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals
Scientific Reports·2018· 74 citedOpen Access
Degradative intrabody for selective elimination of pathogenic TDP-43 aggregates in vitro and in murine embryos’ cerebrum
Journal of the Neurological Sciences·2017
Development of an effective technology for inductive differentiation from bone marrow-derived mononuclear cells to neuroprotective microglia
Journal of the Neurological Sciences·2017
CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS
Scientific Reports·2016· 34 citedOpen Access
小胞体‐Golgi体輸送はPLP1アミノ酸置換により生じたPelizaeus‐Merzbacher病に対する新規な薬物標的として働くであろう
日本人類遺伝学会大会プログラム・抄録集·2016
ER-Golgi transport may serve as a novel drug target for Pelizaeus-Merzbacher disease caused by PLP1 amino acid substitutions
日本人類遺伝学会大会プログラム・抄録集·2016
Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine
Experimental Biology and Medicine·2014· 8 cited
Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)
Journal of Biological Chemistry·2013· 86 citedOpen Access
Depletion of Molecular Chaperones from the Endoplasmic Reticulum and Fragmentation of the Golgi Apparatus Associated with Pathogenesis in Pelizaeus-Merzbacher Disease
Journal of Biological Chemistry·2013· 32 citedOpen Access
Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43
PLoS ONE·2012· 30 citedOpen Access
Effect of curcumin in a mouse model of Pelizaeus–Merzbacher disease
Molecular Genetics and Metabolism·2012· 23 cited
Establishment of a medicine against the endoplasmic reticulum stress in Pelizaeus-Merzbacher disease
Neuroscience Research·2011
Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling
Brain Research·2009· 21 cited
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Frequent Co-authors

Makoto Urushitani(10), Akemi Shodai(8), Misao Onuma(8), Takashi Ayaki(7), Kazuhiko Ohashi(7), Chihiro Sugimoto(7), Masaharu Ogawa(6), Ryōsuke Takahashi(6), Yurika Numata(6), Ryota Hikiami(5), Sumio Minamiyama(5), Ken Inoue(5), Ryo Goitsuka(4), Daisuke Kitamura(4), Yasuhiro Kon(4), Shoko Nakamura(4), Mitsuharu Hattori(3), Katsuhiko Mikoshiba(3), Tsukasa Uchida(3), Hidefumi Ito(3)