Christopher U.T. Hellen

State University of New York — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

70h-index19.3kcitations154works3.62yr avg
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Research Topics

RNA and protein synthesis mechanisms(116), Viral Infections and Immunology Research(74), RNA modifications and cancer(55), RNA Research and Splicing(46), Plant Virus Research Studies(25)

Publications154 total

Structural Studies of Nedicistrovirus IRES-Driven, Initiation Factor-independent Translation Shed Light on Key Steps of Eukaryotic Translation Elongation
2025Open Access
The translation initiation factor DHX29 appears to pull on mRNA in a direction opposite to scanning
2025· 1 citedOpen Access
The mechanism of ribosomal recruitment during translation initiation on Type 2 IRESs
2025· 1 citedOpen Access
Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus
Viruses·2025Open Access
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin
Genes & Development·2025· 7 citedOpen Access
Inconsistencies in the published rabbit ribosomal rRNAs: a proposal for uniformity in sequence and site numbering
RNA·2025· 1 citedOpen Access
Superkiller complex problems expose a cancer-cell vulnerability
Nature·2025· 2 cited
The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin
2024· 2 citedOpen Access
Inconsistencies in the published rabbit ribosomal rRNAs: a proposal for uniformity in sequence and site numbering
2024· 1 citedOpen Access
Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes
Viruses·2024· 5 citedOpen Access
Genetic mechanisms underlying the structural elaboration and dissemination of viral internal ribosomal entry sites
2024· 4 citedOpen Access
Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC
Nucleic Acids Research·2024· 19 citedOpen Access
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g
Genes & Development·2023· 20 citedOpen Access
The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs
Nucleic Acids Research·2023· 13 citedOpen Access
<i>In vitro</i> reconstitution of SARS CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g
2023· 3 citedOpen Access
Initiation of translation on nedicistrovirus and related intergenic region IRESs by their factor-independent binding to the P site of 80S ribosomes
RNA·2023· 7 citedOpen Access
Molecular architecture of <scp>40S</scp> translation initiation complexes on the hepatitis C virus <scp>IRES</scp>
The EMBO Journal·2022· 40 citedOpen Access
Horizontal gene transfer as a mechanism for the promiscuous acquisition of distinct classes of IRES by avian caliciviruses
Nucleic Acids Research·2021· 14 citedOpen Access
Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA
2021· 3 citedOpen Access
Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs
Nucleic Acids Research·2021· 16 citedOpen Access
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Frequent Co-authors

Tatyana V. Pestova(43), Victoria Kolupaeva(9), Andrey V. Pisarev(8), Ivan B. Lomakin(6), Eckard Wimmer(6), Maxim A. Skabkin(5), Ivan N. Shatsky(4), Vera P. Pisareva(4), Olga V. Skabkina(4), Vidya Dhote(4), Anett Unbehaun(4), Richard J. Jackson(3), Ivan N. Shatsky(3), Amédée des Georges(3), Joachim Frank(3), Yaser Hashem(3), Sylvain de Breyne(3), Peter Sarnow(2), Evgeny V. Pilipenko(2), Vadim I. Agol(2)