Timothy J. Maziasz

Medicine · Health Sciences

16h-index1.6kcitations27works0.02yr avg
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Research Topics

Inflammatory mediators and NSAID effects(16), Pharmacogenetics and Drug Metabolism(11), Estrogen and related hormone effects(8), Synthesis of β-Lactam Compounds(5), Neuropeptides and Animal Physiology(3)

Publications27 total

Chapter 16. Predicting Hepatotoxicity <i>In Vivo</i>
RSC drug discovery/RSC drug discovery series·2011
Predictive toxicology approaches for small molecule oncology drugs
Cambridge University Press eBooks·2010· 1 cited
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
Bioorganic & Medicinal Chemistry Letters·2010· 324 citedOpen Access
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates
Bioorganic & Medicinal Chemistry Letters·2010· 36 citedOpen Access
Predictive Toxicology Approaches for Small Molecule Oncology Drugs
Toxicologic Pathology·2010· 18 citedOpen Access
Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity
Journal of Pharmacology and Experimental Therapeutics·2005· 77 cited
Role of Cyclooxygenase-2 in Cytokine-induced β-Cell Dysfunction and Damage by Isolated Rat and Human Islets
Journal of Biological Chemistry·2004· 48 citedOpen Access
Role of Preclinical Metabolism and Pharmacokinetics in The Development of Celecoxib
2004· 5 cited
The Development of Drugs That Target Cyclooxygenase-2
Humana Press eBooks·2003
The Development of Drugs That Target Cyclooxygenase-2
Humana Press eBooks·2003· 3 citedOpen Access
Reply from the Authors
Kidney International·2002
Pharmacology of cyclooxygenase-2 inhibition in the kidney
Kidney International·2002· 82 citedOpen Access
Comparative Analysis of Pharmacologic and/or Genetic Disruption of Cyclooxygenase-1 and Cyclooxygenase-2 Function in Female Reproduction in Mice*
Endocrinology·2001· 97 citedOpen Access
Pharmacokinetics of Celecoxib after Oral Administration in Dogs and Humans: Effect of Food and Site of Absorption
Journal of Pharmacology and Experimental Therapeutics·2001· 285 cited
COX-2???Specific Inhibitors: Definition of a New Therapeutic Concept
American Journal of Therapeutics·2001· 58 cited
Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Celecoxib in Rats
Drug Metabolism and Disposition·2000· 130 cited
Evidence for Polymorphism in the Canine Metabolism of the Cyclooxygenase 2 Inhibitor, Celecoxib
Drug Metabolism and Disposition·1999· 116 cited
Cyclooxygenase-2 (COX-2) Plays a Significant Role in Regulating the Fetal Ductus Asteriosus In Vivo and In Vitro
Pediatric Research·1999· 1 citedOpen Access
Interspecies Differences in Renal Localization of Cyclooxygenase Isoforms: Implications in Nonsteroidal Antiinflammatory Drug-Related Nephrotoxicity
Toxicologic Pathology·1998· 202 cited
Preclinical pharmacology of celecoxib and demonstration of superior GI safety compared with NSAIDs in dogs
1998· 4 cited
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Frequent Co-authors

Susan K. Paulson(7), Kanwar Nasir M. Khan(6), Carl L. Alden(5), John J. Talley(4), Peter C. Isakson(4), Karen Seibert(4), Kenneth M. Verburg(3), James K. Gierse(3), Jane L. Wang(2), David C. Limburg(2), Matthew J. Graneto(2), Jeffery Carter(2), Susan M. Jessen(2), Yvette M. Lawal(2), Christopher J. Gresk(2), Catherine M. Venturini(2), Roderick T. Bunch(2), Jacqueline Brassard(2), Alane Koki(2), Dale L. Morris(2)