Craig Freeman

Hudson Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index4.6kcitations89works0.02yr avg
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Research Topics

Proteoglycans and glycosaminoglycans research(53), Glycosylation and Glycoproteins Research(31), Carbohydrate Chemistry and Synthesis(21), Fibroblast Growth Factor Research(12), Platelet Disorders and Treatments(10)

Publications89 total

Molecular iodine is not responsible for cytotoxicity in iodophors
Journal of Hospital Infection·2022· 15 citedOpen Access
Neutralizing the pathological effects of extracellular histones with small polyanions
Nature Communications·2020· 76 citedOpen Access
Heparanase and Type 1 Diabetes
Advances in experimental medicine and biology·2020· 14 cited
Loss of intra-islet heparan sulfate is a highly sensitive marker of T1DM progression in humans
Yearbook of pediatric endocrinology·2018· 2 cited
Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans
PLoS ONE·2018· 39 citedOpen Access
Identification of Heparin Modifications and Polysaccharide Inhibitors of Plasmodium falciparum Merozoite Invasion That Have Potential for Novel Drug Development
Antimicrobial Agents and Chemotherapy·2017· 31 citedOpen Access
S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation
Scientific Reports·2015· 9 citedOpen Access
Islet Heparan Sulfate but Not Heparan Sulfate Proteoglycan Core Protein Is Lost During Islet Isolation and Undergoes Recovery Post-Islet Transplantation
American Journal of Transplantation·2015· 29 citedOpen Access
Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3
Chemistry & Biology·2014· 73 citedOpen Access
The accumulation of circulating histones on heparan sulphate in the capillary glycocalyx of the lungs
Biomaterials·2013· 46 cited
Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation
Matrix Biology·2013· 66 citedOpen Access
Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease
IUBMB Life·2013· 85 cited
Heparanase and Autoimmune Diabetes
Frontiers in Immunology·2013· 54 citedOpen Access
Heparanase and Vascular Endothelial Growth Factor Expression Is Increased in Hypoxia-Induced Retinal Neovascularization
Investigative Ophthalmology & Visual Science·2012· 19 citedOpen Access
Size and sulfation are critical for the effect of heparin on <scp>APP</scp> processing and Aβ production
Journal of Neurochemistry·2012· 15 citedOpen Access
The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes
Transcription·2012· 60 citedOpen Access
Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation.
PubMed·2012· 26 cited
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2012
Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-d-glucuronidase (heparanase)
Science & Engineering Faculty·2012
Effects of glycosaminoglycans on the level of β- and α-secretase and APP processing in Tg2576 primary cortical cells
Figshare·2012Open Access
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Frequent Co-authors

Christopher R. Parish(28), John J. Hopwood(10), Charmaine J. Simeonovic(5), Andrew Ziolkowski(4), C. Phillip Morris(4), Vito Ferro(4), David H. Small(4), Mark D. Hulett(3), Vicki Levidiotis(3), David A. Power(3), Anna Bezos(3), Fui Jiun Choong(3), Kathryn J. Brown(2), Sarah K. Popp(2), Rachel Li(2), Di Yu(2), Paul N. Smith(2), Chris Tikellis(2), Mark E. Cooper(2), Glenn A. Jacobson(2)