Mark G. Qian

Takeda (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index1.6kcitations98works2.92yr avg
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Research Topics

Ubiquitin and proteasome pathways(22), Monoclonal and Polyclonal Antibodies Research(18), Lymphoma Diagnosis and Treatment(17), Biosimilars and Bioanalytical Methods(16), Microtubule and mitosis dynamics(14)

Publications98 total

Dual-SplitNluc: A Spectrally Resolved Bioluminescence Platform Enabling Duplex Homogeneous Immunoassays
2026Open Access
Dual-SplitNluc: A Spectrally Resolved Bioluminescence Platform Enabling Duplex Homogeneous Immunoassays
2026Open Access
2025 White Paper on Recent Issues in Bioanalysis: What is the Future of Bioanalytical LIMS? AI/ML Integration in Bioanalysis; Tear Sample Collection; Radiolabeled Mass Balance Studies; Chiral Assays; Bioanalysis of Antibody-Oligonucleotide &amp; Bicycle Drug Conjugates ( <u>PART 1A</u> – Recommendations on Mass Spectrometry Assays, Chromatography, Sample Preparation and Regulated Bioanalysis Sampling, Validating, Analyzing &amp; Reporting <u>PART 1B</u> – Regulatory Agencies’ Input on Regulated Bioanalysis/BMV)
Bioanalysis·2025Open Access
Heterogeneous and evolving epitope landscape of clinical anti-drug antibodies against multidomain biotherapeutic: a case study of TAK-186
mAbs·2025· 1 citedOpen Access
Two-Cycle Immunoaffinity Enrichment Strategy with Acid Treatment to Enhance Biotherapeutics Assay Sensitivity in Tissues
Analytical Chemistry·2025Open Access
Rapid and Wash-Free Anti-Drug Antibody Assay Enabled by a Complementary Nanoluciferase Biosensor
Analytical Chemistry·2025· 2 cited
Differential Protein Precipitation-Based GalNAc-siRNA Sample Preparation with LC/MS Method Development Workflow in Plasma
Analytical Chemistry·2025· 4 citedOpen Access
Rapid and wash-free anti-drug antibody assay enabled by the complementary nanoluciferase biosensor
2025Open Access
2024 White Paper on Recent Issues in Bioanalysis: Three Way-Cross Validation; Urine Clinical Analysis; Automated Methods; Regulatory Queries on Plasma Protein Binding; Automated Biospecimen Management; ELN Migration; Ultra-Sensitivity Mass Spectrometry ( <u>Part 1A</u> – Recommendations on Advanced Strategies for Mass Spectrometry Assays, Chromatography, Sample Preparation and BMV/Regulated Bioanalysis <u>Part 1B</u> - Regulatory Agencies’ Inputs on Regulated Bioanalysis/BMV)
Bioanalysis·2025· 4 citedOpen Access
Feasibility of a direct binding electrochemiluminescence assay to detect anti-drug antibodies against therapeutic peptides
Journal of Pharmaceutical and Biomedical Analysis·2024Open Access
Exploring the diagnostic potential of miRNA signatures in the Fabry disease serum: A comparative study of automated and manual sample isolations
PLoS ONE·2024Open Access
Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay
mAbs·2024· 1 citedOpen Access
Exploring the Diagnostic Potential of miRNA Signatures in the Fabry Disease Serum: A Comparative Study of Automated and Manual Sample Isolations
2024· 1 citedOpen Access
T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics
mAbs·2024· 30 citedOpen Access
Feasibility of a Direct Binding Electrochemiluminescence Assay to Detect Antibodies Against Therapeutic Peptides
SSRN Electronic Journal·2024Open Access
2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline &amp; Global Harmonization; Hybrid Assays; Oligonucleotides &amp; ADC; Non-Liquid &amp; Rare Matrices; Regulatory Inputs ( <u>Part 1A</u> – Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline &amp; Global Harmonization <u>Part 1B</u> - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene &amp; Cell Therapy and Vaccine)
Bioanalysis·2023· 14 cited
Multifaceted Approach for Quantification and Enzymatic Activity of Iduronate-2-Sulfatase to Support Developing Gene Therapy for Hunter Syndrome
The AAPS Journal·2023· 3 cited
Development of a Highly Sensitive Hybrid LC/MS Assay for the Quantitative Measurement of CTLA-4 in Human T Cells
Molecules·2023· 5 citedOpen Access
Supplementary Figure 3 from MLN0905, a Small-Molecule &lt;i&gt;PLK1&lt;/i&gt; Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
2023Open Access
Supplementary Table 2 from MLN0905, a Small-Molecule &lt;i&gt;PLK1&lt;/i&gt; Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma
2023Open Access
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Frequent Co-authors

David M. Lubman(11), Hiroshi Sugimoto(10), Susan Chen(9), Linlin Dong(7), Jing-Tao Wu(4), Debra Liao(4), Fabio Garofolo(4), Stephen Vinter(4), Bradley Stringer(4), Adnan O. Abu‐Yousif(4), Melissa Gallery(3), Jing‐Tao Wu(3), Gerald T. Miwa(3), Michael X. Li(3), Suresh K. Balani(3), Neeraj Gupta(3), Eric Woolf(3), Seongeun Cho(3), Akiko Ishii‐Watabe(3), Amanda Wilson(3)