Damian Smuga

Celon Pharma (Poland) — Poland

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index270citations25works2.32yr avg
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Research Topics

Advanced biosensing and bioanalysis techniques(3), Receptor Mechanisms and Signaling(3), Synthesis and Characterization of Heterocyclic Compounds(3), Diabetes Treatment and Management(2), DNA and Nucleic Acid Chemistry(2)

Publications25 total

Identification of pyrrolo[2,3-d]pyrimidine-based dual MERTK and FLT3 inhibitor: Hit-to-lead, machine learning, modeling, synthesis, and biological evaluation
European Journal of Pharmaceutical Sciences·2026Open Access
Development of Prediction Capabilities for High-Throughput Screening of Physiochemical Properties by Biomimetic Chromatography
Molecules·2025· 1 citedOpen Access
Simultaneous 5-HT1BR agonist/5-HT6R antagonist action as a potential treatment of Parkinson’s disease and its comorbidities
Journal of Pharmacology and Experimental Therapeutics·2024· 5 citedOpen Access
Preclinical characterization of CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 for gastric, bladder, and squamous cell lung cancer
Frontiers in Oncology·2024· 3 citedOpen Access
Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery
Biomedicines·2023· 42 citedOpen Access
Implementation of QbD Approach to the Development of Chromatographic Methods for the Determination of Complete Impurity Profile of Substance on the Preclinical and Clinical Step of Drug Discovery Studies
International Journal of Molecular Sciences·2022· 14 citedOpen Access
Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I—Indole Derivatives
Pharmaceuticals·2022· 4 citedOpen Access
Design, Synthesis, and Development of Pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part II—Benzimidazole Derivatives
Pharmaceuticals·2022· 9 citedOpen Access
Discovery and development of CPL207280 as new GPR40/FFA1 agonist
European Journal of Medicinal Chemistry·2021· 14 cited
CPL207280, a Novel G Protein–Coupled Receptor 40/Free Fatty Acid Receptor 1–Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals
Molecular Pharmacology·2021· 12 citedOpen Access
Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
Pharmaceuticals·2021· 39 citedOpen Access
CCDC 2076005: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021· 1 citedOpen Access
Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma
PLoS ONE·2020· 6 citedOpen Access
P.105 The study of molecular changes induced by CPL500-036, a potential novel anti-dyskinetic drug, in 6-OHDA rat model of Parkinson's disease
European Neuropsychopharmacology·2020· 1 cited
Synthesis and characterization of novel classes of PDE10A inhibitors - 1H-1,3-benzodiazoles and imidazo[1,2-a]pyrimidines
European Journal of Medicinal Chemistry·2018· 24 citedOpen Access
Syntheses and antiproliferative activities of novel phosphatidylcholines containing dehydroepiandrosterone moieties
Steroids·2017· 8 cited
Synthesis of 28-<i>O</i>-(1,2-Diacyl-<i>sn</i>-glycero-3-phospho)-betulin
Synthetic Communications·2012· 6 cited
An LC method for the analysis of phosphatidylcholine hydrolysis products and its application to the monitoring of the acyl migration process
Talanta·2012· 31 cited
Synthesis of dehydroepiandrosterone analogues modified with phosphatidic acid moiety
Steroids·2010· 8 cited
Histamine modified 2′-deoxyriboadenosine – Potential copper binding site in DNAzymes
Journal of Inorganic Biochemistry·2010· 5 cited
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Frequent Co-authors

Krzysztof Dubiel(13), Maciej Wieczorek(13), Jerzy Pieczykolan(10), Lidia Gurba-Bryśkiewicz(7), Krzysztof Mulewski(7), Mikołaj Matłoka(7), Elżbieta Sochacka(6), Mateusz Mach(5), Monika Delis(4), Jakub Dominowski(4), Joanna Hucz‐Kalitowska(4), Aleksandra Stańczak(4), Wioleta Maruszak(3), Rafał Moszczyński-Pętkowski(3), Czesław Wawrzeńczyk(3), Katarzyna Bazydło‐Guzenda(3), Paweł Buda(3), Radosław Dzida(3), Filip Stelmach(3), Marcin Zagozda(3)