David J. Mangelsdorf

Southwestern Medical Center — United States

Medicine · Health Sciences

130h-index85.3kcitations322works3.02yr avg
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Research Topics

Cholesterol and Lipid Metabolism(72), Drug Transport and Resistance Mechanisms(67), Estrogen and related hormone effects(61), Retinoids in leukemia and cellular processes(49), Fibroblast Growth Factor Research(42)

Publications318 total

FGF21 acting on the noradrenergic nervous system protects against influenza virus infection
Proceedings of the National Academy of Sciences·2025Open Access
Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate
Proceedings of the National Academy of Sciences·2025· 6 citedOpen Access
Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers
Frontiers in Oncology·2023· 3 citedOpen Access
FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system
Cell Metabolism·2023· 41 citedOpen Access
Effect of PPARγ-K107 SUMOylation on insulin sensitivity and adiposity in mice
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2023Open Access
FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons
2022Open Access
The ‘nuclear option’ revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections
Molecular and Biochemical Parasitology·2022· 5 citedOpen Access
Reply to G Taubes, MI Friedman, and V Torres-Carot et al
American Journal of Clinical Nutrition·2022· 4 cited
The energy balance model of obesity: beyond calories in, calories out
American Journal of Clinical Nutrition·2022· 280 citedOpen Access
The ‘Nuclear Option’ Revisited: Confirmation of Ss-Daf-12 Function and Therapeutic Potential in Strongyloides Stercoralis and Other Parasitic Nematode Infections
SSRN Electronic Journal·2022Open Access
The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3
PLoS Pathogens·2021· 15 citedOpen Access
Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis
eLife·2021· 18 citedOpen Access
Author response: Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis
2021Open Access
Characterization of the Endogenous DAF-12 Ligand and Its Use as an Anthelmintic Agent in <i>Strongyloides stercoralis</i>
2021Open Access
FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes
Cell Reports·2021· 94 citedOpen Access
Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite <i>Strongyloides stercoralis</i>
Proceedings of the National Academy of Sciences·2021· 23 citedOpen Access
Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation
Parasites & Vectors·2020· 14 citedOpen Access
Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy
Science Translational Medicine·2020· 51 citedOpen Access
Additional file 1 of Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation
Figshare·2020Open Access
Additional file 2 of Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation
Figshare·2020Open Access
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Frequent Co-authors

Ronald M. Evans(16), Steven A. Kliewer(14), Joyce J. Repa(11), Angie L. Bookout(7), Kazuhiko Umesono(6), Richard A. Heyman(5), Estelita S. Ong(5), Xunshan Ding(5), Makoto Makishima(4), Takeshi Inagaki(4), Moosa Mohammadi(4), Mark R. Haussler(4), Peter Tontonoz(4), Ruth T. Yu(4), Kevin D. Lustig(3), Bei Shan(3), Antonio Moschetta(3), James A. Richardson(3), Bethany A. Janowski(3), Regina Goetz(3)