Joan C. Gorga

Immunology and Microbiology · Life Sciences

28h-index9.8kcitations58works0.02yr avg
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Research Topics

Immunotherapy and Immune Responses(26), T-cell and B-cell Immunology(24), Monoclonal and Polyclonal Antibodies Research(15), Immune Cell Function and Interaction(14), Coagulation, Bradykinin, Polyphosphates, and Angioedema(12)

Publications58 total

Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. <i>Nature</i>. 1994. 368: 711-718.
PubMed·2018
Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. <i>Nature</i>. 1994. 368: 711–718
The Journal of Immunology·2018
Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39.
PubMed·2015· 6 cited
Pillars Article: Three-Dimensional Structure of the Human Class II Histocompatibility Antigen HLA-DR1. <i>Nature</i>. 1993. 364: 33–39
The Journal of Immunology·2014
Design, Synthesis, and Biological Evaluation of Peptidomimetic Inhibitors of Factor XIa as Novel Anticoagulants
Journal of Medicinal Chemistry·2006· 70 citedOpen Access
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa
Bioorganic & Medicinal Chemistry Letters·2006· 58 citedOpen Access
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine
Bioorganic & Medicinal Chemistry Letters·2006· 63 citedOpen Access
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 6-Carbamimidoyl-4-(3-hydroxy-2-methyl-benzoylamino)-naphthalene-2-carboxylic acid methyl ester
2005
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with N-(7-Carbamimidoyl-naphthalen-1-yl)-3-hydroxy-2-methyl-benzamide
2005
Factor XI complexed with 3-hydroxypropyl 3-(7-amidinonaphthalene-1-carboxamido)benzenesulfonate
2005
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide
2005
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3-Chloro-phenyl)-2-hydroxy-acetylamino]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide
2005
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomimetic Inhibitor
2005
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenyl)guanidine
2005
Factor XI catalytic domain complexed with 2-guanidino-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl nicotinate
2005
Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions
Journal of Biological Chemistry·2004· 56 citedOpen Access
Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin
2004
Crystal Structure of the FXIa Catalytic Domain in Complex with Ecotin Mutant (EcotinP)
2004
Epigenetic Silencing of the<i>CIITA</i>Gene and Posttranscriptional Regulation of Class II MHC Genes in Ocular Melanoma Cells
Investigative Ophthalmology & Visual Science·2004· 27 cited
The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine
Journal of Biological Chemistry·2004· 63 citedOpen Access
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Frequent Co-authors

Jack L. Strominger(18), Theodore S. Jardetzky(14), Don C. Wiley(11), Lawrence J. Stern(10), Robert G. Urban(10), Michael J. Rynkiewicz(9), Robert E. Babine(9), Jerry H. Brown(8), James E. Strickler(8), J L Strominger(7), F. Bibbins(7), Harold V. Meyers(6), D. C. Wiley(5), Roman M. Chicz(5), Pramod S. Pandey(5), Dean R. Madden(4), Cynthia V. Stauffacher(4), Lei Jin(4), Susan Cantin(4), David T. Weaver(4)