Virgil Simplăceanu

Carnegie Mellon University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.6kcitations85works0.02yr avg
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Research Topics

Hemoglobin structure and function(47), Protein Structure and Dynamics(24), Hemoglobinopathies and Related Disorders(19), Advanced NMR Techniques and Applications(19), Neonatal Health and Biochemistry(14)

Publications85 total

Sickle Cell Hemoglobin with Mutation at αHis-50 Has Improved Solubility
Journal of Biological Chemistry·2015· 6 citedOpen Access
New Look at Hemoglobin Allostery
Chemical Reviews·2015· 171 citedOpen Access
Combining perfluorocarbon and superparamagnetic iron‐oxide cell labeling for improved and expanded applications of cellular MRI
Magnetic Resonance in Medicine·2014· 24 citedOpen Access
Role of β/δ101Gln in Regulating the Effect of Temperature and Allosteric Effectors on Oxygen Affinity in Woolly Mammoth Hemoglobin
Biochemistry·2013· 7 citedOpen Access
Solution Structure and Dynamics of Human Hemoglobin in the Carbonmonoxy Form
Biochemistry·2013· 19 citedOpen Access
Autoxidation and Oxygen Binding Properties of Recombinant Hemoglobins with Substitutions at the αVal-62 or βVal-67 Position of the Distal Heme Pocket
Journal of Biological Chemistry·2013· 19 citedOpen Access
Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock
2013· 4 cited
Roles of Amino Acid Residues in Woolly Mammoth Hemoglobin on the Temperature Effect of Oxygen Binding
Biophysical Journal·2013Open Access
A Biochemical–Biophysical Study of Hemoglobins from Woolly Mammoth, Asian Elephant, and Humans
Biochemistry·2011· 15 cited
HUMAN NEUROGLOBIN FUNCTIONS AS A REDOX REGULATED NITRITE REDUCTASE
The FASEB Journal·2011· 2 cited
Human Neuroglobin Functions as a Redox-regulated Nitrite Reductase
Journal of Biological Chemistry·2011· 280 citedOpen Access
An Investigation of the Distal Histidyl H-Bonds in Oxyhemoglobin: Effects of Temperature, pH, and Inositol Hexaphosphate
Biophysical Journal·2011Open Access
An Investigation of the Distal Histidyl Hydrogen Bonds in Oxyhemoglobin: Effects of Temperature, pH, and Inositol Hexaphosphate
Biochemistry·2010· 17 cited
Intravenous Anesthetic Diazepam Does Not Induce Amyloid-β Peptide Oligomerization but Diazepam Co-administered with Halothane Oligomerizes Amyloid-β Peptide: An NMR Study
Journal of Alzheimer s Disease·2010· 25 cited
A Biophysical-Biochemical Comparison of Hemoglobins from Mammoth, Asian Elephant, and Human
Biophysical Journal·2010Open Access
Heme Coordination and Nitrite Reductase Activity of Human Neuroglobin
Free Radical Biology and Medicine·2010
Interfacial and Distal-Heme Pocket Mutations Exhibit Additive Effects on the Structure and Function of Hemoglobin
Biochemistry·2008· 30 citedOpen Access
Effector-Induced Structural Fluctuation Regulates the Ligand Affinity of an Allosteric Protein: Binding of Inositol Hexaphosphate Has Distinct Dynamic Consequences for the T and R States of Hemoglobin
Biochemistry·2008· 28 citedOpen Access
Insights into the Solution Structure of Human Deoxyhemoglobin in the Absence and Presence of an Allosteric Effector
Biochemistry·2007· 30 citedOpen Access
A Comparative NMR Study of the Polypeptide Backbone Dynamics of Hemoglobin in the Deoxy and Carbonmonoxy Forms
Biochemistry·2007· 35 citedOpen Access
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Frequent Co-authors

Chien Ho(43), Nancy T. Ho(21), Jonathan A. Lukin(6), Yue Yuan(6), Ming Zou(5), Patricia F. Cottam(5), Tong-Jian Shen(5), Sarata C. Sahu(4), Susan R. Dowd(3), Tsuei‐Yun Fang(3), Qingguo Gong(3), Janel L. Giovannelli(3), Nico Tjandra(3), Ming F. Tam(2), Tzu-Hsiang Shen(2), Dan E. Demco(2), Doug Barrick(2), Gordon S. Rule(2), Michael C. Schrader(2), Xiangjin Song(2)