Masahiko Chikuma

Osaka University of Pharmaceutical Sciences — Japan

Medicine · Health Sciences

22h-index1.8kcitations131works0.02yr avg
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Research Topics

Metal complexes synthesis and properties(30), Analytical chemistry methods development(22), Molecular Sensors and Ion Detection(15), DNA and Nucleic Acid Chemistry(12), Magnetism in coordination complexes(12)

Publications131 total

CCDC 1901041: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
Associative intraligand substitution of anticancer azolato-bridged compounds without a square-pyramidal intermediate: Formation of a unique tetranuclear, µ3-1,2,3-triazolato-N1,N2,N3-bridged Pt(II) compound
Inorganica Chimica Acta·2019· 2 cited
Interaction of platinum agents, cisplatin, carboplatin and oxaliplatin against albumin <i>in vivo</i> rats and <i>in vitro</i> study using inductively coupled plasma‐mass spectrometory
Biopharmaceutics & Drug Disposition·2019· 34 cited
Does Carboplatin Change to Cisplatin?
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)·2018Open Access
A Novel Analytical Method of Cisplatin Using the HPLC with a Naphthylethyl Group Bonded with Silica Gel (πNAP) Column
Biological and Pharmaceutical Bulletin·2016· 9 citedOpen Access
Second- and higher-order structural changes of DNA induced by antitumor-active tetrazolato-bridged dinuclear platinum(II) complexes with different types of 5-substituent
Journal of Inorganic Biochemistry·2013· 25 cited
Synthesis of antitumor azolato-bridged dinuclear platinum(ii) complexes with in vivo antitumor efficacy and unique in vitro cytotoxicity profiles
Metallomics·2013· 40 citedOpen Access
CCDC 922832: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
Solvolysis and cytotoxicity of dinuclear ruthenium(II)-2,2′-bipyridine complexes with various bridged-ligands
Inorganica Chimica Acta·2012· 10 cited
A circular dichroism study uncovers a two-step interaction of antitumor azolato-bridged dinuclear platinum(ii) complexes with calf thymus DNA
Metallomics·2012· 23 citedOpen Access
An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(ii) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles
Metallomics·2012· 32 citedOpen Access
抗腫瘍性テトラゾラト架橋の二核Pt(II)錯体によるDNAコンホメーション変化
金属の関与する生体関連反応シンポジウム講演要旨集·2012
Highly Efficient DNA Compaction Mediated by an In Vivo Antitumor-Active Tetrazolato-Bridged Dinuclear Platinum(II) Complex
Inorganic Chemistry·2011· 35 cited
Cover Picture: A Tetrazolato‐Bridged Dinuclear Platinum(II) Complex Exhibits Markedly High in vivo Antitumor Activity against Pancreatic Cancer (ChemMedChem 6/2011)
ChemMedChem·2011Open Access
A Tetrazolato‐Bridged Dinuclear Platinum(II) Complex Exhibits Markedly High in vivo Antitumor Activity against Pancreatic Cancer
ChemMedChem·2011· 56 cited
The phosphate clamp: a small and independent motif for nucleic acid backbone recognition
Nucleic Acids Research·2010· 60 citedOpen Access
Suppression by cobalt (II) and enhancement by iron (II) ions of DNA damage induced by 2,2'-azobis (2-amidinopropane) dihydrochloride
Biomedical research on trace elements·2010
Characteristic effect of an anticancer dinuclear platinum(II) complex on the higher-order structure of DNA
JBIC Journal of Biological Inorganic Chemistry·2010· 22 cited
Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells
International Journal of Pharmaceutics·2010· 59 cited
Cisplatin and its analogues induce a significant change in the higher-order structure of long duplex DNA
Chemical Physics Letters·2009· 15 cited
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Frequent Co-authors

Seiji Komeda(16), Takaji Sato(11), Hisashi Tanaka(10), Hisashi Tanaka(9), Yutaka Saito(8), Masaki Mifune(8), Morio Nakayama(8), Junichi Odō(6), Yoshimasa Tanaka(6), J. Reedijk(5), Yuko Yoshikawa(5), Suzuyo Nakashima(4), Tomoo Tanaka(4), Masako Uemura(4), Kenichi Yoshikawa(4), Yoshiki Mino(4), Yoshito Okabayashi(4), Terumichi Nakagawa(4), Martin Lutz(3), Anthony L. Spek(3)