Marja Talikka

Philip Morris International (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index3.5kcitations103works2.02yr avg
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Research Topics

Bioinformatics and Genomic Networks(28), Computational Drug Discovery Methods(20), Chronic Obstructive Pulmonary Disease (COPD) Research(12), Gene Regulatory Network Analysis(12), Gene expression and cancer classification(12)

Publications103 total

Quantitative modeling of in vitro data using an adverse outcome pathway for the risk assessment of decreased lung function in humans
Toxicology Letters·2024· 2 citedOpen Access
P01-01: A quantitative adverse outcome pathway for predicting medium-term lung function evolution after switching from combustible cigarettes to heated tobacco products
Toxicology Letters·2023
Tobacco Alkaloid Assessment in a DSS-Induced Colitis Mouse Model with a Fully Humanized Immune System
International Journal of Molecular Sciences·2023· 6 citedOpen Access
Causal biological network models for reactive astrogliosis: a systems approach to neuroinflammation
Scientific Reports·2022· 4 citedOpen Access
Causal Biological Network Model for Inflammasome Signaling Applied for Interpreting Transcriptomic Changes in Various Inflammatory States
International Journal of Inflammation·2022· 3 citedOpen Access
Identifying neuroinflammation in omics datasets with a computational biological network model of reactive astrogliosis
Alzheimer s & Dementia·2021
Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish
Frontiers in Genetics·2021· 7 citedOpen Access
Systems biology approach highlights mechanistic differences between Crohn’s disease and ulcerative colitis
Scientific Reports·2021· 24 citedOpen Access
Systems Approaches for Toxicological Assessment of Nanomaterials
Nanotoxicology·2021
<i>In Vivo</i> Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy
Journal of Natural Products·2021· 12 citedOpen Access
A Systems-Based Approach to Toxicity Testing
Elsevier eBooks·2021
A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products
Toxicology Research and Application·2021· 7 citedOpen Access
List of Contributors
Elsevier eBooks·2021
Causal biological network model of endothelial dysfunction as a predictor of arterial aging
Atherosclerosis·2020
Systems Toxicology Approach for Testing Chemical Cardiotoxicity in Larval Zebrafish
Chemical Research in Toxicology·2020· 22 citedOpen Access
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
Archives of Toxicology·2020· 18 citedOpen Access
The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts
Scientific Reports·2020· 30 citedOpen Access
P109 Construction of a suite of computable biological network models focused on inflammatory bowel disease
Journal of Crohn s and Colitis·2020Open Access
Applying Systems Toxicology Methods to Drug Safety
Systems Medicine·2019· 2 citedOpen Access
NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks
BMC Bioinformatics·2019· 9 citedOpen Access
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Frequent Co-authors

Julia Hoeng(44), Manuel C. Peitsch(42), Florian Martin(27), Walter K. Schlage(21), Stéphanie Boué(18), Nikolai V. Ivanov(17), Emilija Veljkovic(12), Emmanuel Guedj(12), Yang Xiang(11), Alain Sewer(10), Blaine Phillips(9), Patrick Vanscheeuwijck(9), Michael J. Peck(9), Carole Mathis(9), Bjoern Titz(8), Anita R. Iskandar(8), Grégory Vuillaume(7), Patrice Leroy(7), Jurjen W. Westra(6), Ashraf Elamin(6)