Mary F. Grubb

Bristol-Myers Squibb (United States) — United States

Medicine · Health Sciences

11h-index438citations21works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(5), Pharmacogenetics and Drug Metabolism(4), Analytical Chemistry and Chromatography(3), Neurotransmitter Receptor Influence on Behavior(2), HIV Research and Treatment(2)

Publications21 total

Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors
ACS Medicinal Chemistry Letters·2021· 5 citedOpen Access
Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1
ACS Medicinal Chemistry Letters·2021· 26 citedOpen Access
Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT<sub>2C</sub>Receptor Agonists
Journal of Medicinal Chemistry·2017· 16 citedOpen Access
Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies
Bioorganic & Medicinal Chemistry Letters·2015· 14 citedOpen Access
Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup
Bioorganic & Medicinal Chemistry Letters·2015· 8 citedOpen Access
Identification of a Nonbasic Melanin Hormone Receptor 1 Antagonist as an Antiobesity Clinical Candidate
Journal of Medicinal Chemistry·2014· 20 cited
Effect of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Impact on Modeling CYP3A-Mediated Drug-Drug Interactions
Drug Metabolism and Disposition·2013· 36 citedOpen Access
A Semi-Automated Method For The Integrated Evaluation of Half-Life And Metabolic Soft Spots of Discovery Compounds
Bioanalysis·2012· 8 cited
Quantitative estimation of circulating metabolites without synthetic standards by ultra‐high‐performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction
Rapid Communications in Mass Spectrometry·2011· 33 cited
Algorithm for Thorough Background Subtraction of High-Resolution LC/MS Data: Application to Obtain Clean Product Ion Spectra from Nonselective Collision-Induced Dissociation Experiments
Analytical Chemistry·2009· 27 cited
In vitro and in vivo effects of the arylamine human immunodeficiency virus protease inhibitor 4R-(4alpha,5alpha,6beta, 7beta)-1-[(3-(1-imidazoylcarbamoyl)phenyl)methyl]-3-[(3-aminophenyl)m ethyl]hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-2H-1, 3-diazepin-2-one (SD894) on rat hepatic cytochrome P450 2B and 3A.
PubMed·1997· 3 cited
Determination of a HIV protease inhibitor (DMP 450) in animal and human plasma by solid-phase extraction and high-performance liquid chromatography
Journal of Chromatography B Biomedical Sciences and Applications·1996
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450
Chemistry & Biology·1996· 148 citedOpen Access
A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs
Biopharmaceutics & Drug Disposition·1994· 18 cited
Pharmacokinetics of HIV protease inhibitor DMP 323 in rats and dogs.
Drug Metabolism and Disposition·1994· 8 cited
ChemInform Abstract: Antiinflammatory 4,5‐Diarylpyrroles: Synthesis and QSAR.
ChemInform·1994
Antiinflammatory 4,5-Diarylpyrroles: Synthesis and QSAR
Journal of Medicinal Chemistry·1994· 41 citedOpen Access
Serum stimulation of UDP-glucose dehydrogenase activity in Swiss 3T3 fibroblasts.
PubMed·1993· 11 cited
Effect of High-Protein Diet on Pyrimidine Synthesis and Response to PALA in Mouse Tissues
JNCI Journal of the National Cancer Institute·1993· 8 cited
Derivatization of n-methyl and cyclic amino acids with dimethylformamide dimethyl acetal
Journal of Chromatography A·1989· 8 cited
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Frequent Co-authors

Christine Huang(5), Jeffrey A. Robl(4), Anthony V. Azzara(4), Mary Jane Cullen(4), Brian J. Murphy(4), Jonathan L. Josephs(3), Kimberly A. Foster(3), William N. Washburn(3), Pratik Devasthale(3), Mary Ann Pelleymounter(3), Daniel Angelo Longhi(3), Ning Huang(3), Neil Flynn(3), Kenneth W. Rohrbach(3), James J. Devenny(3), Suzanne Rooney(3), Michael A. Thomas(3), Susan Glick(3), Helen E. Godonis(3), Susan J. Harvey(3)