Alan J. Williams

Swansea University — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index36.2kcitations226works0.02yr avg
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Research Topics

Ion channel regulation and function(138), Cardiac electrophysiology and arrhythmias(115), Neuroscience and Neuropharmacology Research(28), Neuroscience and Neural Engineering(21), Ion Channels and Receptors(18)

Publications225 total

The ryanodine receptor: advances in structure and organization
Current Opinion in Physiology·2017· 9 citedOpen Access
Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart
JACC. Clinical electrophysiology·2017· 26 citedOpen Access
Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia
The Journal of Physiology·2016· 4 citedOpen Access
Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating
Scientific Reports·2016Open Access
Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain
Journal of Cell Science·2016· 27 citedOpen Access
Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1
Cell Research·2016· 92 citedOpen Access
Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor
British Journal of Pharmacology·2016· 18 citedOpen Access
Cardiac Ryanodine Receptor Channel Gating is Modified during Blocker-Induced Changes in Ion Permeation
Biophysical Journal·2016Open Access
Fundamental Gating Defects of Sudden Cardiac Death-Linked Mutant Cardiac Ryanodine Receptors Determine Ca2+ Release Dynamics in Cells
Biophysical Journal·2016Open Access
Effect of Flecainide Derivatives on Sarcoplasmic Reticulum Ca2+ Release Confirms a Lack of Direct Action on the Cardiac Ryanodine Receptor
Biophysical Journal·2016Open Access
Characterisation of cardiomyocytes derived from human induced pluripotent stem cells as monolayers
The Lancet·2016
A Systematized Approach to Investigate Ca2+ Synchronization in iPSC-Derived Cardiomyocyte Networks
Biophysical Journal·2016Open Access
A Systemized Approach to Investigate Ca2+ Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes
Frontiers in Cell and Developmental Biology·2016· 6 citedOpen Access
Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides
Scientific Reports·2015· 89 citedOpen Access
The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2
Circulation Research·2015· 97 citedOpen Access
Molecular cloning, characterisation and mRNA expression of the ryanodine receptor from the peach-potato aphid, Myzus persicae
Gene·2014· 10 citedOpen Access
Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors
Cardiovascular Research·2014· 19 citedOpen Access
Insights into the Gating Mechanism of the Ryanodine-Modified Human Cardiac Ca2+-Release Channel (Ryanodine Receptor 2)
Molecular Pharmacology·2014· 5 cited
The Cardiac Ryanodine Receptor (RyR2): Investigating Mechanisms of Gating at the Selectivity Filter
Biophysical Journal·2014Open Access
Functional Characterization of the Cardiac Ryanodine Receptor Pore-Forming Region
PLoS ONE·2013· 9 citedOpen Access
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Frequent Co-authors

Rebecca Sitsapesan(11), Tyson A. Clark(6), John E. Blume(5), Andrew Tinker(5), Simon Cawley(4), Melissa Cline(4), Hui Wang(4), A R Lindsay(4), Kenneth T. MacLeod(3), Michelle K. Staples(2), Anthony Schweitzer(2), Charles W. Sugnet(2), Gang Lu(2), Nathan Salomonis(2), Julia Bailey‐Serres(2), Duncan J. West(2), Judith A. Airey(2), John L. Sutko(2), Stephen J. McGarry(2), N. Lowri Thomas(2)