Sabine Hadidaꝉ

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

21h-index4.9kcitations53works0.02yr avg
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Research Topics

Fluorine in Organic Chemistry(16), Chemical Synthesis and Analysis(12), Cystic Fibrosis Research Advances(10), Catalytic Cross-Coupling Reactions(9), Catalytic C–H Functionalization Methods(7)

Publications53 total

Case History: Orkambi® (Ivacaftor/Lumacaftor), for the Treatment of Cystic Fibrosis Patients who are Homozygous for the F508del CFTR Mutation
Medicinal chemistry reviews·2018
Discovery of <i>N</i>-(2,4-Di-<i>tert</i>-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a Potent and Orally Bioavailable CFTR Potentiator
Journal of Medicinal Chemistry·2014· 110 citedOpen Access
ChemInform Abstract: Addition of α‐Lithiated Nitriles to Azaheterocycles.
ChemInform·2014
Corrigendum to “Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists” [Bioorg. Med. Chem. Lett. 24 (2014) 845–849]
Bioorganic & Medicinal Chemistry Letters·2014
Addition of α-Lithiated Nitriles to Azaheterocycles
Synlett·2014· 5 cited
Identification of potent CNS-penetrant thiazolidinones as novel CGRP receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2014· 24 citedOpen Access
Case History
Annual reports in medicinal chemistry·2014· 7 cited
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
Proceedings of the National Academy of Sciences·2011· 1.1k citedOpen Access
Rescue of the protein folding defect in cystic fibrosis in vitro by the investigational small molecule, VX-809
Journal of Cystic Fibrosis·2010· 10 cited
CFTR Modulators for the Treatment of Cystic Fibrosis
Annual reports in medicinal chemistry·2010· 16 cited
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
Proceedings of the National Academy of Sciences·2009· 1.2k citedOpen Access
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
Journal of Cystic Fibrosis·2009· 65 citedOpen Access
Pharmacological Rescue of Mutant CFTR Function for the Treatment of Cystic Fibrosis
Topics in medicinal chemistry·2008· 12 cited
Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules
American Journal of Physiology-Lung Cellular and Molecular Physiology·2006· 495 cited
Direct Synthesis of Trimethyl(2‐phenoxyethyl)silanes from Aromatic Fluorides.
ChemInform·2005
Direct synthesis of trimethyl(2-phenoxyethyl)silanes from aromatic fluorides
Tetrahedron Letters·2005· 21 cited
Regioselective Synthesis of 3‐Substituted Indoles: 3‐Ethylindole
Organic Syntheses·2003· 2 cited
Synthesis of Tris(2‐Perfluorohexylethyl)Tin Hydride: A Highly Fluorinated Tin Hydride with Advantageous Features of Easy Purification
Organic Syntheses·2003· 3 cited
ChemInform Abstract: Experimental Techniques in Fluorous Synthesis: A User′s Guide
ChemInform·2001· 3 cited
Experimental techniques in fluorous synthesis: a user’s guide
2000· 10 cited
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Frequent Co-authors

Dennis P. Curran(18), Mercedes Amat(16), Joan Bosch(16), Peter D. J. Grootenhuis(9), S. SATHYANARAYANA(9), Fredrick Van Goor(8), Paul A. Negulescu(6), Caroline J. Decker(5), Sunyoung Kim(5), Bill Burton(4), Eric R. Olson(4), Melissa A. Ashlock(4), Armido Studer(4), Mats Larhed(4), Corey L. Anderson(4), Anna Hazlewood(3), Jason McCartney(3), Jeffrey H. Stack(3), Jeffrey J. Wine(3), Zhiyong Luo(3)