Michael Klichinsky

Carisma Therapeutics (United States) — United States

Medicine · Health Sciences

20h-index5.9kcitations91works17.92yr avg
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Research Topics

CAR-T cell therapy research(74), Immune cells in cancer(26), Monoclonal and Polyclonal Antibodies Research(20), Phagocytosis and Immune Regulation(18), Immunotherapy and Immune Responses(14)

Publications90 total

In vivo chimeric antigen receptor (CAR)-T cell therapy
Nature Reviews Drug Discovery·2025· 16 cited
Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis
Science Translational Medicine·2025· 7 cited
Abstract P2-12-17: A Phase 1, First-in-Human study of autologous monocytes engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants with HER2 overexpressing solid tumors
Clinical Cancer Research·2025
FRI-041 Enhancing restorative macrophage functions through genetic modification improves liver fibrosis in MASH models
Journal of Hepatology·2025
Author Correction: Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models
Nature Communications·2025· 4 citedOpen Access
CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial
Nature Medicine·2025· 127 cited
Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models
Nature Communications·2025· 62 citedOpen Access
Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models
immuneACCESS·2024· 2 cited
659 A phase 1, first-in-human study of autologous monocytes engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants with HER2 overexpressing solid tumors
Regular and Young Investigator Award Abstracts·2024Open Access
329 Pre-clinical efficacy of a novel anti-GPC3 <i>in vivo</i> CAR-M for hepatocellular carcinoma
Regular and Young Investigator Award Abstracts·2024· 1 citedOpen Access
A phase 1, first-in-human study of autologous monocytes engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants with HER2-overexpressing solid tumors.
Journal of Clinical Oncology·2024· 5 cited
Abstract PO2-04-08: Translational insights from a phase 1, first-in-human (FIH) clinical trial of the anti-HER2 CAR macrophage CT-0508 in participants with HER2 positive metastatic breast cancer and other HER2 overexpressing solid tumors
Cancer Research·2024· 6 cited
Abstract 5249: Macrophages expressing synthetic cytokine receptors reverse IL10-mediated immunosuppression within solid tumors and promote adaptive immunity
Cancer Research·2024· 3 cited
389 Engineered microenvironment converters (EM-C): macrophages expressing synthetic cytokine receptors reverse immunosuppressive signals in solid tumors
Regular and Young Investigator Award Abstracts·2023Open Access
635 A phase 1, first in human (FIH) study of autologous macrophages engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants (pts) with HER2 overexpressing solid tumors
Regular and Young Investigator Award Abstracts·2023· 1 citedOpen Access
307 CAR-Macrophages with custom intronic shRNA exhibit enhanced efficacy against solid tumors
Regular and Young Investigator Award Abstracts·2023Open Access
1514 <i>In vivo</i> CAR-M: redirecting endogenous myeloid cells with mRNA for cancer immunotherapy
2023· 2 citedOpen Access
A phase 1, first-in-human (FIH) study of autologous macrophages engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants (pts) with HER2-overexpressing solid tumors.
Journal of Clinical Oncology·2023· 13 cited
Abstract CT241: A phase 1, first-in-human (FIH) study of autologous anti-HER2 chimeric antigen receptor macrophage (CAR-M) in participants (pt) with HER2 overexpressing solid tumors
Cancer Research·2023· 2 cited
Abstract 4053: A mesothelin targeting chimeric antigen receptor macrophage (CAR-M) for solid tumor immunotherapy: pre-clinical development of CT-1119
Cancer Research·2023· 2 cited
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Frequent Co-authors

Saar Gill(32), Olga Shestova(28), Marco Ruella(19), Carl H. June(19), Saad S. Kenderian(18), Thomas Condamine(16), Daniel Cushing(12), Miriam Kim(10), Sascha Abramson(10), Rehman Qureshi(9), Yuan Yuan(8), Débora Barton(8), Rashid Gabbasov(8), Linara Gabitova(8), Yumi Ohtani(8), Simon F. Lacey(7), Ramona F. Swaby(7), Yara Abdou(7), Amy Ronczka(7), J. Joseph Melenhorst(6)