Lifeng Xu

Anhui Provincial Hospital — China

Medicine · Health Sciences

17h-index1.9kcitations40works2.02yr avg
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Research Topics

Telomeres, Telomerase, and Senescence(23), CRISPR and Genetic Engineering(8), Chromosomal and Genetic Variations(6), RNA Interference and Gene Delivery(5), DNA Repair Mechanisms(4)

Publications40 total

Dual-polarization fluorescent DNA framework nanomaterials
Chem·2026
Identification and evaluation of glutamine-related gene characteristics based on multi-omics to predict the prognosis of patients with colorectal cancer
Journal of Translational Medicine·2026Open Access
Host Microenvironment Reprogramming by Saccharides Overcomes Lung Barriers for mRNA Therapeutics
2025Open Access
From Sequence to System: Enhancing IVT mRNA Vaccine Effectiveness through Cutting-Edge Technologies
Molecular Pharmaceutics·2024· 6 cited
Disruption of<i>Zfh3</i>abolishes mulberry‐specific monophagy in silkworm larvae
Insect Science·2024· 4 citedOpen Access
High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform
Nature Communications·2023· 75 citedOpen Access
<i>Bmmp</i> influences wing morphology by regulating anterior–posterior and proximal–distal axes development
Insect Science·2022· 30 cited
ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma
2021
Expansion of targetable sites for the ribonucleoprotein-based CRISPR/Cas9 system in the silkworm Bombyx mori
BMC Biotechnology·2021· 11 citedOpen Access
<i>Bmmp</i> influences wing shape by regulating anterior-posterior and proximal-distal axis development
2021Open Access
The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment
Proceedings of the National Academy of Sciences·2021· 7 citedOpen Access
The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment
2020Open Access
Both the classical and alternative non-homologous end joining pathways contribute to the fusion of drastically shortened telomeres induced by TRF2 overexpression
Cell Cycle·2019· 5 citedOpen Access
An N-terminal Flag-tag impairs TPP1 regulation of telomerase function
Biochemical and Biophysical Research Communications·2019· 7 cited
Discovery of clubroot-resistant genes in Brassica napus by transcriptome sequencing
Genetics and Molecular Research·2016· 8 citedOpen Access
Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions
Nature Communications·2015· 79 citedOpen Access
Telomerase inhibition in TIN2-R282H heterozygotes and TIN2-WT cells leads to similar rates of telomere erosion.
Figshare·2015Open Access
Heterozygous TIN2-R282H mutation induces progressive telomere shortening, but not gross telomere deprotection, in HCT116 cells.
Figshare·2015Open Access
TIN2-R282H mutation reduces colocalization between endogenous telomerase RNA and telomeres.
Figshare·2015Open Access
Heterozygous TIN2-R282H mutation decreases the frequency of telomere extension by telomerase.
Figshare·2015Open Access
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Frequent Co-authors

Elizabeth H. Blackburn(10), Bradley A. Stohr(5), Yunlong Zou(4), Fangyin Dai(4), Xiaoling Tong(4), K. Frank Amanda(4), Cihangir Duy(4), W. Qu Roy(4), A. Stohr Bradley(4), Segal David J.(4), Diane Pennica(3), Arnold J. Levine(3), Shang Li(3), Hai Hu(3), Ranjodh Sandhu(3), Derek Wei(3), Madhav Sharma(3), Ryan B. Corcoran(2), David J. Segal(2), Bernadette Nera(2)