Marina Karaghiosoff

Medicine · Health Sciences

16h-index2.3kcitations23works0.02yr avg
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Research Topics

Cytokine Signaling Pathways and Interactions(15), Immune Response and Inflammation(9), Immune Cell Function and Interaction(9), interferon and immune responses(6), NF-κB Signaling Pathways(5)

Publications23 total

<i>Tyk2<sup>−/−</sup></i> and <i>Tyk2<sup>K923E</sup></i> mice show similarly increased susceptibility to virus infection.
Figshare·2015Open Access
TYK2<sup>K923E</sup> is enzymatically inactive and generation of <i>Tyk2<sup>K923E</sup></i> mice.
Figshare·2015Open Access
Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance
Transgenic Research·2014· 21 cited
TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo
PLoS ONE·2012· 76 citedOpen Access
PS2-084 Dissection of kinase-dependent and -independent functions of Tyk2 in immunity to infection and tumor-surveillance
Cytokine·2011
PS2-095. Conditional knockout of tyrosine kinase 2 (Tyk2): dissecting cell type-specific functions in innate IL-17 production
Cytokine·2011
Generation of mice with a conditional Stat1 null allele
Transgenic Research·2011· 31 cited
Tristetraprolin‐driven regulatory circuit controls quality and timing of mRNA decay in inflammation
Molecular Systems Biology·2011· 109 citedOpen Access
TYK2 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 CONTRIBUTE TO INTESTINAL I/R INJURY
Shock·2008· 11 cited
Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo
Immunobiology·2007· 9 cited
A time- and dose-dependent STAT1 expression system.
BMC Biotechnology·2006· 6 citedOpen Access
Novel Functions of Tyrosine Kinase 2 in the Antiviral Defense against Murine Cytomegalovirus
The Journal of Immunology·2005· 61 cited
TYK2 is a key regulator of the surveillance of B lymphoid tumors
Journal of Clinical Investigation·2004· 60 citedOpen Access
TYK2 is a key regulator of the surveillance of B lymphoid tumors
Journal of Clinical Investigation·2004· 62 cited
Control of <i>Leishmania major</i> in the absence of Tyk2 kinase
European Journal of Immunology·2004· 32 cited
Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity
Immunity·2003· 291 citedOpen Access
A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity
Proceedings of the National Academy of Sciences·2003· 131 citedOpen Access
Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice
Journal of Biological Chemistry·2003· 203 citedOpen Access
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
Nature Immunology·2003· 362 cited
IFNs and STATs in innate immunity to microorganisms
Journal of Clinical Investigation·2002· 20 cited
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Frequent Co-authors

Mathias Müller(22), Thomas Kolbe(12), Birgit Strobl(9), Thomas Rülicke(8), Thomas Decker(7), Pavel Kovarik(6), Caroline Lassnig(5), Nicole R. Leitner(5), Claus Vogl(4), Raimund M. Vielnascher(4), Christian Semper(4), Barbara Wallner(4), Julianna Kobolák(4), Christian Bogdan(3), Ralf Steinborn(3), Silvia Stockinger(3), Michaela Prchal‐Murphy(3), Christian Gausterer(3), Ingeborg Teppner-Klymiuk(3), Simone Müller(3)