Shaalee Dworski

University of Toronto — Canada

Medicine · Health Sciences

12h-index596citations32works0.02yr avg
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Research Topics

Lysosomal Storage Disorders Research(13), Sphingolipid Metabolism and Signaling(11), Nerve injury and regeneration(3), Metabolomics and Mass Spectrometry Studies(3), Neutrophil, Myeloperoxidase and Oxidative Mechanisms(3)

Publications32 total

Epidermal <scp>1‐</scp><i>O</i>‐acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes
Lipids·2022· 7 citedOpen Access
Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury
Stem Cell Reports·2020· 45 citedOpen Access
Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2020· 11 cited
Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency
Scientific Reports·2018· 22 citedOpen Access
Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency
American Journal of Physiology-Lung Cellular and Molecular Physiology·2017· 37 citedOpen Access
Improving diagnosis, understanding, and treatment of Farber disease
TSpace (University of Toronto)·2017Open Access
Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34 + Cells for Correction of Fabry Disease
Molecular Therapy — Methods & Clinical Development·2017· 45 citedOpen Access
Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities
American Journal Of Pathology·2017· 49 citedOpen Access
Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice
BBA Clinical·2017· 43 citedOpen Access
Proof-of-concept studies underlying enzyme replacement therapy for acid ceramidase deficiency
Molecular Genetics and Metabolism·2017· 1 cited
Acid Ceramidase Deficiency is characterized by a unique plasma cytokine and ceramide profile that is altered by therapy
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2016· 41 citedOpen Access
Relative Distribution of Gb <sub>3</sub> Isoforms/Analogs in Nod/Scid/Fabry Mice Tissues Determined by Tandem Mass Spectrometry
Bioanalysis·2016· 16 citedOpen Access
Acid ceramidase deficiency leads to multiple skin abnormalities in a mouse model of Farber disease
Molecular Genetics and Metabolism·2016· 2 cited
Markedly perturbed hematopoiesis in acid ceramidase deficient mice
Haematologica·2015· 19 citedOpen Access
Spatial distribution of brain ceramides in an acid ceramidase deficient murine model: Subsequent histological manifestations and functional deficits
Molecular Genetics and Metabolism·2015
Detection and Distribution of Sphingolipids in Tissue by FTICR MALDI-Imaging Mass Spectrometry
2015· 3 cited
Profiling of glycosphingolipids for relative organ distribution in a pure strain of Fabry mice
Clinical Biochemistry·2014
On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging
Analytical Chemistry·2014· 72 citedOpen Access
Direct Genesis of Functional Rodent and Human Schwann Cells from Skin Mesenchymal Precursors
Stem Cell Reports·2014· 66 citedOpen Access
Farber disease: characterization of behavior and brain pathology in a new murine model
Molecular Genetics and Metabolism·2014
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Frequent Co-authors

Jeffrey A. Medin(25), Thierry Levade(10), Bryan Au(6), E. Ellen Jones(5), Richard R. Drake(5), Josefina Casas(4), Gemma Fabriàs(4), Edward H. Schuchman(4), Darius Bägli(4), Jakub Sikora(4), Mustafa A. Kamani(4), Makoto Yoshimitsu(4), Alexandra Berger(4), Caren Furlonger(4), Christopher J. Paige(4), Abdulfatah M. Alayoubi(3), B C Y Au(3), Stéphane Carpentier(3), Calogera M. Simonaro(3), Freda D. Miller(3)