Gizelle M. McCarthy

Vertex Pharmaceuticals (United States) — United States

Medicine · Health Sciences

6h-index267citations11works6.02yr avg
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Research Topics

Renal Diseases and Glomerulopathies(6), Chronic Lymphocytic Leukemia Research(3), Neuroinflammation and Neurodegeneration Mechanisms(3), Coagulation, Bradykinin, Polyphosphates, and Angioedema(2), Immune Response and Inflammation(1)

Publications11 total

Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease
Nature Communications·2025· 16 citedOpen Access
Small Molecule APOL1 Channel Inhibitor Reduces Proteinuria, Rescues Podocyte Injury, and Reverses eGFR Decline in an APOL1-Mediated Kidney Disease Mouse Model
Journal of the American Society of Nephrology·2024
Small Molecule APOL1 Inhibitors as a Precision Medicine Approach for APOL1-mediated Kidney Disease
2024· 2 citedOpen Access
Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes
Pflügers Archiv - European Journal of Physiology·2022· 18 citedOpen Access
Targeting mTOR Signaling Improved Kidney Function in APOL1 Risk Variant Mice with Chronic Exposure to Inflammatory Stimuli
Journal of the American Society of Nephrology·2021
Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease
Disease Models & Mechanisms·2021· 61 citedOpen Access
Microglial-specific transcriptome changes following chronic alcohol consumption
Neuropharmacology·2017· 57 cited
Chronic ethanol consumption: role of <scp>TLR3/TRIF</scp>‐dependent signaling
Addiction Biology·2017· 69 citedOpen Access
CNS cell-type localization and LPS response of TLR signaling pathways
F1000Research·2017· 44 citedOpen Access
Neuroimmune signaling and microglia in chronic ethanol consumption
2017Open Access
Dataset containing the following six files: ISH localization images, ISH images, knockout animal qPCR, Sal-LPS qPCR data, Sal-LPS western blots and validation western blots.
Faculty of 1000 Research Ltd·2017Open Access

Frequent Co-authors

Angelo Blasio(5), Yuri A. Blednov(4), Courtney R. Bridges(3), R. Adron Harris(3), Lena B. Schaller(3), Shrijal S. Shah(3), David J. Friedman(3), Martin R. Pollak(3), Leslie Dakin(3), Shyamesh Kumar(3), Jennifer Proctor(3), Timothy J. Senter(3), Brinley F. Furey(3), Olivia G Donovan(2), Jose M. Magraner(2), Calum F. Tattersfield(2), Balajikarthick Subramanian(2), A H Fortier(2), Evanthia Nanou(2), James Mann(2)