Irina M. Armean

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index23.5kcitations47works40.02yr avg
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Research Topics

Genomics and Rare Diseases(25), Genomics and Phylogenetic Studies(13), Bioinformatics and Genomic Networks(7), RNA and protein synthesis mechanisms(6), CRISPR and Genetic Engineering(5)

Publications46 total

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Nature Communications·2025· 3 citedOpen Access
The effect of LRRK2 loss-of-function variants in humans
UNC Libraries·2025Open Access
Author Correction: The effect of LRRK2 loss-of-function variants in humans
UNC Libraries·2025Open Access
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
Nature·2024· 157 citedOpen Access
A genomic mutational constraint map using variation in 76,156 human genomes
Nature·2023· 1.1k citedOpen Access
Inferring compound heterozygosity from large-scale exome sequencing data
Nature Genetics·2023· 30 citedOpen Access
Comparative evolutionary analyses of eight whitefly Bemisia tabaci sensu lato genomes: cryptic species, agricultural pests and plant-virus vectors
BMC Genomics·2023· 18 citedOpen Access
Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes (Nature Communications, (2020), 11, 1, (2539), 10.1038/s41467-019-12438-5)
Nature Communications·2021· 1 citedOpen Access
Annotating and prioritizing genomic variants using the Ensembl Variant Effect Predictor—A tutorial
Human Mutation·2021· 83 citedOpen Access
Ensembl 2022
Nucleic Acids Research·2021· 2.1k citedOpen Access
The value of primary transcripts to the clinical and non‐clinical genomics community: Survey results and roadmap for improvements
Molecular Genetics & Genomic Medicine·2021· 6 citedOpen Access
Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans
Nature·2021· 57 citedOpen Access
Annotating and prioritising genomic variants using the Ensembl Variant Effect Predictor - a tutorial
2021· 3 citedOpen Access
THE VALUE OF PRIMARY TRANSCRIPTS TO THE CLINICAL AND NON-CLINICAL GENOMICS COMMUNITY: SURVEY RESULTS AND ROADMAP FOR IMPROVEMENTS. AUTHORS
2021Open Access
The value of primary transcripts to the clinical and non-clinical genomics community: survey results and roadmap for improvements.
2021· 1 citedOpen Access
Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans
Nature·2021· 95 citedOpen Access
Author Correction: Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals
Nature Communications·2021· 1 citedOpen Access
Author Correction: Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes
Nature Communications·2021· 2 citedOpen Access
Author Correction: The effect of LRRK2 loss-of-function variants in humans
Nature Medicine·2021Open Access
The ELIXIR Human Copy Number Variations Community: building bioinformatics infrastructure for research
F1000Research·2020· 6 citedOpen Access
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Frequent Co-authors

Jessica Alföldi(25), Beryl B. Cummings(24), Laurent C. Francioli(23), Juliana C.N. Chan(20), Konrad J. Karczewski(19), Kristen M. Laricchia(19), Nicola Whiffin(19), Qingbo S. Wang(18), Ryan L. Collins(18), Laura D. Gauthier(18), Nicholas A. Watts(18), Eric Banks(18), Eric Vallabh Minikel(18), Louis Bergelson(18), Stacey Gabriel(18), Yossi Farjoun(17), Anne O’Donnell‐Luria(17), Kristian Cibulskis(17), Kristen M. Connolly(17), Miguel Covarrubias(17)