Arleen B. Rifkind

Cornell University — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

33h-index3.4kcitations93works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(28), Toxic Organic Pollutants Impact(18), Eicosanoids and Hypertension Pharmacology(18), Metabolism and Genetic Disorders(17), Porphyrin Metabolism and Disorders(15)

Publications93 total

Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR
Journal of Biological Chemistry·2021· 39 citedOpen Access
Organ-specific effects on glycolysis by the dioxin-activated aryl hydrocarbon receptor
PLoS ONE·2020· 10 citedOpen Access
Synthesis and Characterization of Polybromo- and Polybromochloro-Dibenzo-p-Dioxins and Dibenzofurans
2018· 1 cited
NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion
Scientific Reports·2017· 41 citedOpen Access
Heart as a target organ in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity: Decreased /3-adrenergic responsiveness and evidence of increased intracellular calcium (isoproterenol/force frequency/guinea pig papillary muscle/polyhalogenated aromatic hydrocarbons)
2016
Increases in Levels of Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids (EETs and DHETs) in Liver and Heart in Vivo by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and in Hepatic EET:DHET Ratios by Cotreatment with TCDD and the Soluble Epoxide Hydrolase Inhibitor AUDA
Drug Metabolism and Disposition·2013· 23 citedOpen Access
Aryl Hydrocarbon Receptor Activation by Dioxin Targets Phosphoenolpyruvate Carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-inducible Poly(ADP-ribose) Polymerase (TiPARP)
Journal of Biological Chemistry·2013· 30 citedOpen Access
Competing interests: Expanding rapidly
Nature·2012· 2 citedOpen Access
Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight
Chemico-Biological Interactions·2011· 19 cited
Identification of the Aryl Hydrocarbon Receptor Target Gene TiPARP as a Mediator of Suppression of Hepatic Gluconeogenesis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and of Nicotinamide as a Corrective Agent for This Effect
Journal of Biological Chemistry·2010· 118 citedOpen Access
UVR Exposure Sensitizes Keratinocytes to DNA Adduct Formation
Cancer Prevention Research·2009· 42 citedOpen Access
Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase
Archives of Biochemistry and Biophysics·2007· 13 citedOpen Access
INDUCTION OF CYP1A AND CYP2-MEDIATED ARACHIDONIC ACID EPOXYGENATION AND SUPPRESSION OF 20-HYDROXYEICOSATETRAENOIC ACID BY IMIDAZOLE DERIVATIVES INCLUDING THE AROMATASE INHIBITOR VOROZOLE
Drug Metabolism and Disposition·2006· 28 cited
CYP1A in TCDD Toxicity and in Physiology–with Particular Reference to CYP Dependent Arachidonic Acid Metabolism and other Endogenous Substrates
Drug Metabolism Reviews·2006· 99 cited
Sunlight Generates Multiple Tryptophan Photoproducts Eliciting High Efficacy CYP1A Induction in Chick Hepatocytes and In Vivo
Toxicological Sciences·2005· 60 citedOpen Access
Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Archives of Biochemistry and Biophysics·2002· 15 cited
Ventricular Preexcitation Sensitive to Flecainide in Late Stage Chick Embryo ECGs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Impairs Inotropic but Not Chronotropic or Dromotropic Responses to Isoproterenol and Confers Resistance to Flecainide
Toxicology and Applied Pharmacology·2000· 12 cited
TCDD Induces CYP1A4 and CYP1A5 in Chick Liver and Kidney and Only CYP1A4, an Enzyme Lacking Arachidonic Acid Epoxygenase Activity, in Myocardium and Vascular Endothelium
Toxicology and Applied Pharmacology·2000· 34 cited
Olfaction and Symptoms in the Multiple Chemical Sensitivities Syndrome
Preventive Medicine·1999· 41 cited
Transcriptional Activation of AvianCYP1A4andCYP1A5by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Differences in Gene Expression and Regulation Compared to MammalianCYP1A1andCYP1A2
Toxicology and Applied Pharmacology·1999· 46 citedOpen Access
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Frequent Co-authors

Silvia Diani-Moore(8), Attallah Kappas(7), Griff T. Ross(5), Steven S. Gross(4), Maureen Gannon(4), Chull S. Song(4), Peter Gillette(4), Howard E. Kulin(4), Maria I. New(4), Charles M. Cargille(3), Deidre Gilday(3), Erin Labitzke(3), Charis A. Lee(2), Payal Ram(2), Akio Kanetoshi(2), Liliana Canga(2), C A Lee(2), Lenore S. Levine(2), John Whysner(2), Vincent T. Covello(2)