Binghui Shen

Changchun University of Science and Technology — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

55h-index9.8kcitations230works3.02yr avg
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Research Topics

DNA Repair Mechanisms(113), CRISPR and Genetic Engineering(38), Epigenetics and DNA Methylation(24), DNA and Nucleic Acid Chemistry(24), RNA modifications and cancer(21)

Publications230 total

Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells
2025Open Access
XPF mediates 3’ flap processing for FEN1-independent Okazaki fragment maturation
2025Open Access
Arginine methylation-dependent METTL14-SMN interaction regulates RNA m6A homeostasis
EMBO Reports·2025Open Access
JMJD1B-mediated FEN1 demethylation allows timely switching of Okazaki fragment maturation core enzymes to avoid mutagenic flap ligation by PARP1-LIG3
2025· 1 citedOpen Access
DNA2 and MSH2 cooperatively repair stabilized G4 and allow efficient telomere replication
Nature Communications·2025· 3 citedOpen Access
KRAS-induced STN1 (OBFC1) promotes proper CTC1–STN1–TEN1 complex-independent DNA double-strand break repair and cell cycle checkpoint maintenance in pancreatic cancer
Nucleic Acids Research·2025· 2 citedOpen Access
Construction of hollow few-layer MXene nanosheets@Ni–Fe layered double hydroxide microrods for enhanced electrochemical sensing
Talanta·2025· 2 cited
Abstract A004: Integrating high-throughput screening with ligand-based pharmacophore modeling and virtual screening strategies to optimize exonuclease 1 inhibitor design
Clinical Cancer Research·2025· 1 cited
DNA2 and FANCM function in two distinctive pathways in disrupting TERRA R-loops and suppressing replication stress at ALT telomeres
2025· 1 citedOpen Access
Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer Therapy
ACS Chemical Biology·2025· 3 citedOpen Access
Abstract 6865: Discovery and characterization of small molecule inhibitors targeting EXO1 for BRCAness cancer therapy
Cancer Research·2025
Abstract 6996: Integrating high-throughput screening with ligand-based pharmacophore modeling and virtual screening strategies to optimize exonuclease 1 inhibitor design
Cancer Research·2025
Abstract 7199: Synergistic anticancer effects of milciclib and mirdametinib: mechanistic insights into cell cycle arrest, DNA damage, and senescence
Cancer Research·2025
DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication
2025Open Access
Consensus statement on the use of systemic therapies in pancreatic ductal adenocarcinoma in Asia
ESMO Gastrointestinal Oncology·2025Open Access
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
UNC Libraries·2024Open Access
EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication
Nucleic Acids Research·2024· 4 citedOpen Access
Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma
Cell Reports·2024· 6 citedOpen Access
Structure-specific nucleases in genome dynamics and strategies for targeting cancers
Journal of Molecular Cell Biology·2024· 1 citedOpen Access
Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer
Journal for ImmunoTherapy of Cancer·2024· 20 citedOpen Access
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Frequent Co-authors

Li Zheng(20), Junzhuan Qiu(11), Huifang Dai(10), Mian Zhou(10), Zhigang Guo(8), John A. Tainer(6), Changwei Liu(6), David J. Hosfield(5), Qin Huang(5), L. David Finger(4), Purnima Singh(4), Yuejin Hua(4), B.R. Chapados(3), Dongxin Lin(3), Limin Qian(3), Guanjun Gao(3), Lina Zhou(3), Yingjie Wang(3), Judith L. Campbell(3), Songbai Liu(3)