Carolyn M. Nielsen

University of Oxford — United Kingdom

Medicine · Health Sciences

23h-index2.0kcitations51works9.92yr avg
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Research Topics

Malaria Research and Control(26), Mosquito-borne diseases and control(13), Immune Cell Function and Interaction(13), Complement system in diseases(11), T-cell and B-cell Immunology(10)

Publications51 total

Replication Data for: B and T cell responses to pre-erthrocytic R21/Matrix and blood-stage RH5.1/Matrix-M malaria vaccine in endemic settings
Harvard Dataverse·2026Open Access
B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings
2025Open Access
Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection
Nature Communications·2025· 2 citedOpen Access
An experimental model of clinical immunity for human malaria
2025· 1 citedOpen Access
Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children
The Lancet Infectious Diseases·2024· 29 citedOpen Access
Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled phase 2b trial in children
2024· 1 citedOpen Access
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype
Cell·2024· 24 citedOpen Access
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Cell·2024· 13 citedOpen Access
Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial
The Lancet Infectious Diseases·2024· 35 citedOpen Access
First Phase 1b, single-center, age de-escalation trial of the <i>P. falciparum</i> blood-stage malaria vaccine candidate RH5.1/Matrix-M <sup>™</sup> : a delayed boost regimen induces high levels of functional antibodies in 5-17 month old Tanzanian infants
2024Open Access
Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens
Frontiers in Immunology·2024· 8 citedOpen Access
PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial
npj Vaccines·2024· 6 citedOpen Access
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
2023· 3 citedOpen Access
Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype
2023· 10 citedOpen Access
Superior antibody immunogenicity of a viral-vectored RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults
Med·2023· 34 citedOpen Access
PvDBPII-Matrix M elicits polyfunctional antibodies that limit parasite growth in a challenge trial
2023Open Access
Vaccination with <i>Plasmodium vivax</i> Duffy-binding protein inhibits parasite growth during controlled human malaria infection
Science Translational Medicine·2023· 34 citedOpen Access
Superior antibody immunogenicity of a RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults
2023· 2 citedOpen Access
Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1/AS01B malaria vaccine
JCI Insight·2023· 31 citedOpen Access
Human lymphoid tissue sampling for vaccinology
Frontiers in Immunology·2022· 3 citedOpen Access
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Frequent Co-authors

Simon J. Draper(33), Sarah E. Silk(33), Angela M. Minassian(30), Jordan R. Barrett(24), Carole A. Long(19), Kazutoyo Miura(18), Alison M. Lawrie(16), Fay L. Nugent(16), Ababacar Diouf(15), Jee-Sun Cho(14), Nick J. Edwards(13), Mimi M. Hou(13), Ian Poulton(12), Yrene Themistocleous(12), Ruth Payne(11), Thomas A. Rawlinson(11), Doris Quinkert(11), Lloyd D. W. King(11), Jo Salkeld(10), Martin R. Goodier(9)