Seth Winfree

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index4.2kcitations164works6.42yr avg
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Research Topics

Single-cell and spatial transcriptomics(44), Chronic Kidney Disease and Diabetes(35), Cell Image Analysis Techniques(25), Kidney Stones and Urolithiasis Treatments(17), AI in cancer detection(15)

Publications157 total

Uromodulin Inhibits the Nlrc4 Alternative Inflammasome Activation Which Regulates Macrophage-Collecting Duct Crosstalk in Early AKI
Journal of the American Society of Nephrology·2025
Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules
Science Advances·2025· 4 citedOpen Access
Distributed and networked analysis of volumetric image data for remote collaboration of microscopy image analysis
Journal of Medical Imaging·2025· 1 cited
The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control
2025· 11 citedOpen Access
Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules
2024· 1 citedOpen Access
A Quantitative Metric of Confidence for Segmentation of Nuclei in Large Spatially Variable Image Volumes
2024
Tertiary Lymphoid Structures and Late-Stage Lymphangiogenesis at Very-Late Time Points following Ischemic Kidney Injury
Journal of the American Society of Nephrology·2024
A <i>MEF2C</i> transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
2024· 2 citedOpen Access
Acute kidney injury results in long-term alterations of kidney lymphatics in mice
American Journal of Physiology-Renal Physiology·2024· 4 citedOpen Access
Sulfotransferase 1C2 Increases Mitochondrial Respiration by Converting Mitochondrial Membrane Cholesterol to Cholesterol Sulfate
Biochemistry·2024· 2 citedOpen Access
A Quantitative Metric of Confidence For Segmentation of Nuclei in Large Spatially Variable Image Volumes
2024Open Access
CODEX and H&amp;E imaging: cell type mapping, analysis, and visualization pipeline
2024· 1 cited
UNETRIS: transformer-based nuclear instance segmentation for three-dimensional fluorescence microscopy images
2024
Computational integration of CODEX and brightfield histology for cell annotation using deep learning
2024
The chromatin landscape of healthy and injured cell types in the human kidney
Nature Communications·2024· 35 citedOpen Access
An intravenous pancreatic cancer therapeutic: Characterization of CRISPR/Cas9n-modified Clostridium novyi-Non Toxic
PLoS ONE·2023· 7 citedOpen Access
Diverse Immune, Stromal, and Vascular Niches Along the Cortico-Medullary Axis of the Human Kidneys by Integrating 10 Different Modalities Performed on the Same Tissue Block
Journal of the American Society of Nephrology·2023
A Spatial Atlas of the Human Kidneys of Cell Types and Functional Tissue Units Identified in Highly Multiplexed Immunofluorescence Images
Journal of the American Society of Nephrology·2023
Proximal Tubule Neighborhood in AKI, CKD, and Healthy Control Kidney Tissue Using Spatial Transcriptomics
Journal of the American Society of Nephrology·2023
AKI Results in Sustained, Long-Term Alterations of Kidney Lymphatics
Journal of the American Society of Nephrology·2023
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Frequent Co-authors

Tarek M. El‐Achkar(26), Pierre C. Dagher(24), Kenneth W. Dunn(20), Michael T. Eadon(20), Daria Barwinska(18), Michael J. Ferkowicz(16), Katherine J. Kelly(15), Timothy A. Sutton(14), Takashi Hato(13), Ying‐Hua Cheng(12), Blue B. Lake(11), Ricardo Melo Ferreira(11), Paul Hoover(10), Sushrut S. Waikar(10), Krzysztof Kiryluk(10), John R. Sedor(10), Andrew S. Bomback(10), Vivette D. D’Agati(10), James C. Williams(9), Nir Hacohen(9)