Sumera Perveen

University of North Carolina at Chapel Hill — United States

Medicine · Health Sciences

12h-index575citations51works6.42yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

SARS-CoV-2 and COVID-19 Research(12), RNA and protein synthesis mechanisms(10), Computational Drug Discovery Methods(8), Mosquito-borne diseases and control(7), Ubiquitin and proteasome pathways(6)

Publications51 total

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein
UNC Libraries·2025Open Access
A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity
UNC Libraries·2025Open Access
CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13
Journal of Chemical Information and Modeling·2025· 8 citedOpen Access
Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities
Journal of Chemical Information and Modeling·2025· 1 citedOpen Access
Chemical arsenal for helicase Hunters: Striking the toughest targets in antiviral research
Antiviral Research·2025· 1 cited
CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13
2025Open Access
CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13
2025· 2 citedOpen Access
CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13
2025· 1 citedOpen Access
A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity
Scientific Reports·2025· 8 citedOpen Access
Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1
Chemical Science·2025· 4 citedOpen Access
Author response for "Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1"
2024
A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity
2024· 1 citedOpen Access
CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein
Journal of Chemical Information and Modeling·2024· 23 citedOpen Access
A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins
Journal of Medicinal Chemistry·2024· 17 citedOpen Access
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach
Proceedings of the National Academy of Sciences·2024· 24 citedOpen Access
Active Learning Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand Binding Affinities
2024· 3 cited
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of <i>Chikungunya</i> nsP2 Cysteine Protease with Antialphavirus Activity
Journal of Medicinal Chemistry·2024· 24 citedOpen Access
CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson’s Disease associated protein
2024· 5 citedOpen Access
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2
Journal of Chemical Information and Modeling·2024· 10 citedOpen Access
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of <i>Chikungunya</i> nsP2 Cysteine Protease with Anti-alphavirus Activity
2024· 2 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

Pegah Ghiabi(24), Irene Chau(22), Albina Bolotokova(22), Masoud Vedadi(18), Peter J. Brown(18), C.H. Arrowsmith(18), Matthieu Schapira(16), P. Loppnau(16), Elisa Gibson(15), Scott Houliston(14), Fengling Li(13), Aliakbar Khalili Yazdi(13), Levon Halabelian(13), Hong Zeng(12), Almagul Seitova(12), Ashley Hutchinson(12), Rachel Harding(12), Suzanne Ackloo(11), Fengling Li(10), Taraneh Hajian(9)