Koen Augustyns

University of Veterinary Sciences Brno — Czech Republic

Medicine · Health Sciences

50h-index8.3kcitations267works4.22yr avg
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Research Topics

Peptidase Inhibition and Analysis(90), Neuropeptides and Animal Physiology(59), Diabetes Treatment and Management(24), Protease and Inhibitor Mechanisms(23), Chemical Synthesis and Analysis(23)

Publications267 total

Using protease inhibitors to prevent intraperitoneal adhesions: effects of nafamostat mesylate, UAMC-00050, GM6001, and enoxaparin in the cecal ligation and puncture model and the ischemic button model
Surgery Today·2025Open Access
Selective and Orally Bioavailable Dipeptidyl Peptidase 9 Inhibitors with Potent Pyroptosis Induction Properties
Journal of Medicinal Chemistry·2025
Structure–Property Investigation of New “KetoFAPI” Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential
Journal of Medicinal Chemistry·2025· 2 cited
Inhibition of ferroptosis attenuates experimental COPD features
2025
Author Correction: Targeting ferroptosis protects against experimental (multi)organ dysfunction and death
Nature Communications·2025Open Access
Biarylacetamides: a novel class of late-stage autophagy inhibitors
Autophagy Reports·2025Open Access
Highly potent dipeptidyl peptidase 8/9 (DPP8/9) inhibitors designed via relative binding free energy calculations
European Journal of Medicinal Chemistry·2025· 2 cited
The Role of Ferroptosis and Its Inhibition in Chronic Obstructive Pulmonary Disease (COPD)
American Journal of Respiratory and Critical Care Medicine·2025
Ferroptosis Inhibition Attenuates Ischemia-Reperfusion Injury of Pulmonary Grafts during EVLP in a Porcine Model of Prolonged Warm Ischemia
The Journal of Heart and Lung Transplantation·2025
The role of ferroptosis and its inhibition in COPD
2025
Human Transmembrane Serine Protease 2 (TMPRSS2) on Human Seminal Fluid Extracellular Vesicles Is Proteolytically Active
Journal of Extracellular Vesicles·2025· 1 citedOpen Access
Oxazole-Based Ferroptosis Inhibitors with Promising Properties to Treat Central Nervous System Diseases
Journal of Medicinal Chemistry·2025· 7 citedOpen Access
Synthesis and Application of Activity-Based Probes for Serine Proteases
Methods in molecular biology·2025
Recent Advances in the Development of Synthetic Ferroptosis Inhibitors
Medicinal chemistry reviews·2024· 1 cited
Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer
Nature Communications·2024· 15 citedOpen Access
Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease
Cell Death and Differentiation·2024· 27 citedOpen Access
Druglike, <sup>18</sup>F-labeled PET Tracers Targeting Fibroblast Activation Protein
Journal of Medicinal Chemistry·2024· 15 citedOpen Access
Active site-directed probes targeting dipeptidyl peptidases 8 and 9
European Journal of Medicinal Chemistry·2024· 5 citedOpen Access
A high-throughput target-based screening approach for the identification and assessment of <i>Mycobacterium tuberculosis</i> mycothione reductase inhibitors
Microbiology Spectrum·2024· 5 citedOpen Access
Characterization of Structurally Diverse <sup>18</sup>F-Labeled d-TCO Derivatives as a PET Probe for Bioorthogonal Pretargeted Imaging
ACS Omega·2023· 5 citedOpen Access
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Frequent Co-authors

Pieter Van der Veken(26), Anne‐Marie Lambeir(19), Ingrid De Meester(18), Achiel Haemers(18), Jurgen Joossens(12), Simon Scharpé(9), Peter Vandenabeele(8), Paul Cos(6), Kristel Senten(5), Tom Vanden Berghe(5), Sam Hofmans(5), Jonathan D. Cheng(4), Louis Maes(4), Behrouz Hassannia(4), Marie-Berthe Maes(4), Sebastiaan Van Goethem(4), Paul Proost(3), Christine Durinx(3), Gunther Bal(3), Koen Jansen(3)