John H. Wolfe

Children's Hospital of Philadelphia — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

60h-index13.1kcitations303works1.42yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Virus-based gene therapy research(58), Lysosomal Storage Disorders Research(45), Peripheral Artery Disease Management(40), CRISPR and Genetic Engineering(27), Cardiac, Anesthesia and Surgical Outcomes(25)

Publications301 total

Effect of disease progression on CSF-directed AAV gene therapy in a large brain animal model of lysosomal storage disease
Molecular Therapy — Methods & Clinical Development·2025Open Access
Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation
Stem Cell Research & Therapy·2025· 2 citedOpen Access
Choroid plexus-targeted viral gene therapy for alpha-mannosidosis, a prototypical neurometabolic lysosomal storage disease
Human Molecular Genetics·2025· 1 citedOpen Access
Buttock Necrosis Following Uterine Artery Embolization: A Case Report
WOUNDS A Compendium of Clinical Research and Practice·2025· 1 cited
Intracisternal vs intraventricular injection of AAV1 result in comparable, widespread transduction of the dog brain
Gene Therapy·2024· 4 citedOpen Access
Disorders of glycoprotein degradation: α-mannosidosis, β-mannosidosis, fucosidosis, sialidosis, and aspartylglycosaminuria
Elsevier eBooks·2024
Widespread correction of brain pathology in feline alpha-mannosidosis by dose escalation of intracisternal AAV vector injection
Molecular Therapy — Methods & Clinical Development·2024· 3 citedOpen Access
Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs
Stem Cell Reports·2022· 50 citedOpen Access
Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery
Molecular Therapy — Methods & Clinical Development·2022· 6 citedOpen Access
Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex
Cerebral Cortex·2021· 6 citedOpen Access
Progress in gene therapy for neurological disorders
UNC Libraries·2020Open Access
Immunogenetics of Murine and Feline Retroviruses
2020· 2 cited
Subretinal transplantation and survival of hESC-derived photoreceptor precursor cells in normal canine eyes
Investigative Ophthalmology & Visual Science·2020Open Access
Global CNS correction in a large brain model of human alpha-mannosidosis by intravascular gene therapy
Brain·2020· 26 citedOpen Access
In Situ Hybridization for Detection of AAV-Mediated Gene Expression
Methods in molecular biology·2019· 8 citedOpen Access
Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background
The Cerebellum·2017· 3 citedOpen Access
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
Nature Neuroscience·2017· 216 citedOpen Access
Viral Vectors in the CNS ☆
Elsevier eBooks·2017· 6 cited
Viral Vector Gene Delivery to the Brain for Treating Neurogenetic Diseases
2017· 1 cited
Stem Cell Therapy for the Central Nervous System in Lysosomal Storage Diseases
Human Gene Therapy·2016· 20 citedOpen Access
page 1 of 16Next →

Frequent Co-authors

Marco A. Passini(8), Deborah Watson(7), Cassia N. Cearley(4), Luk H. Vandenberghe(4), Michael J. Castle(4), James M. Wilson(4), Mark E. Haskins(4), Stephen Black(3), Charles H. Vite(3), Andrew Nicolaides(3), Evan Y. Snyder(2), Rosanne M. Taylor(2), Jean Bennett(2), Albert M. Maguire(2), Cordula M. Wetzel(2), Roger Kneebone(2), Debra Nestel(2), Nigel W. Fraser(2), Michael K. Parente(2), YogendraSinh H. Raol(2)