Shenghui He

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index5.5kcitations30works10.02yr avg
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Research Topics

Epigenetics and DNA Methylation(5), Pluripotent Stem Cells Research(5), Neurogenesis and neuroplasticity mechanisms(4), Cancer-related Molecular Pathways(3), Telomeres, Telomerase, and Senescence(3)

Publications30 total

miR-29 is an important driver of aging-related phenotypes
Communications Biology·2024· 20 citedOpen Access
Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway
UNC Libraries·2024Open Access
miR-29 is an important driver of aging-related phenotypes
2022· 4 citedOpen Access
Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway
Journal of Biological Chemistry·2022· 11 citedOpen Access
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
Nature Communications·2021· 42 citedOpen Access
Increasing p16INK4aexpression decreases forebrain progenitors and neurogenesis during ageing
UNC Libraries·2020Open Access
BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis
Nature Genetics·2020· 89 citedOpen Access
The first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer
Signal Transduction and Targeted Therapy·2020· 34 citedOpen Access
Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion
UNC Libraries·2020· 4 citedOpen Access
Senescence in Health and Disease
Cell·2017· 1.7k citedOpen Access
Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion
Science Translational Medicine·2017· 144 cited
The Impact of Aging on Cancer Progression and Treatment
2015· 4 cited
Abstract 941: G1T28-1, a novel CDK4/6 inhibitor, protects murine hematopoietic stem and progenitor cells from cytotoxic chemotherapy
Cancer Research·2015· 1 cited
Metamorphic Rock Characteristics of the Main Elements and Discrimination of Tectonic Setting from Au Mining District in Wengake Ximeng, Yunnan
Acta Geologica Sinica - English Edition·2014
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut
Journal of Clinical Investigation·2011· 257 citedOpen Access
Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors
Genes & Development·2011· 118 citedOpen Access
Auto Antibodies Against Retinal Pigment Epithelium in Patients with Atypical Retinopathies
2010· 2 cited
Cellular Immunoreactivity in Patients and Murine Models of Autoimmune Retinopathy
Investigative Ophthalmology & Visual Science·2010
Transcriptional Regulation of Stem Cell Self-Renewal.
Deep Blue (University of Michigan)·2010Open Access
Mechanisms of Stem Cell Self-Renewal
Annual Review of Cell and Developmental Biology·2009· 594 cited
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Frequent Co-authors

Sean J. Morrison(10), Norman E. Sharpless(9), Anna V. Molofsky(5), Ricardo Pardal(4), Janakiraman Krishnamurthy(4), H. Khanna(4), Anand Swaroop(4), Gang Greg Wang(4), Nancy M. Joseph(3), Patrick J. Roberts(3), Jessica A. Sorrentino(3), John Bisi(3), Jay C. Strum(3), Shalom Guy Slutsky(2), Mark J. Kiel(2), Injune Kim(2), Hannah Storrie-White(2), Renger G. Tiessen(2), Karenann M. Makhuli(2), William A. Wargin(2)