Daisuke Aki

Wakayama Medical University — Japan

Immunology and Microbiology · Life Sciences

22h-index3.4kcitations36works11.02yr avg
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Research Topics

Immune Response and Inflammation(8), Cytokine Signaling Pathways and Interactions(8), Acute Myeloid Leukemia Research(7), Immune Cell Function and Interaction(7), Ubiquitin and proteasome pathways(7)

Publications36 total

The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models
Journal of Clinical Investigation·2024· 11 citedOpen Access
SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance
Proceedings of the Japan Academy Series B·2021· 16 citedOpen Access
Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging
International Journal of Molecular Sciences·2021· 24 citedOpen Access
The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control
The Journal of Experimental Medicine·2019· 104 citedOpen Access
The E3 ligase VHL promotes the differentiation of follicular helper T cells through glycolytic-epigenetic pathways
The Journal of Immunology·2019
The E3 ligase VHL controls alveolar macrophage function via metabolic–epigenetic regulation
The Journal of Experimental Medicine·2018· 42 citedOpen Access
Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch
Protein & Cell·2018· 23 citedOpen Access
The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR
Nature Immunology·2018· 46 citedOpen Access
Protein Ubiquitination; A molecular switch for helper T cell differentiation
The Keio Journal of Medicine·2018Open Access
The E3 ligase Itch in immune regulation and beyond
Immunological Reviews·2015· 62 cited
The Ubiquitin System in Immune Regulation
Advances in immunology·2014· 68 cited
Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7
Cancer Cell·2013· 154 citedOpen Access
Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation
Molecular Cell·2012· 63 citedOpen Access
To go or not to go: the “Itchy” effect on the destiny of hematopoietic stem cells
Cell Research·2011· 1 citedOpen Access
The Dynactin Complex Maintains the Integrity of Metaphasic Centrosomes to Ensure Transition to Anaphase
Journal of Biological Chemistry·2010· 9 citedOpen Access
Loss of Titan (Samd9L), a Candidate -7/7q- Responsible Gene Encoding An Actin Remodeling Regulator, Develops MDS/AML in Cooperation with Evi1 or Fbxl10.
Blood·2009
Up-regulation of Survivin by the E2A-HLF Chimera Is Indispensable for the Survival of t(17;19)-positive Leukemia Cells
Journal of Biological Chemistry·2009· 15 citedOpen Access
A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses
The Journal of Immunology·2009· 68 citedOpen Access
Identification of a common microdeletion cluster in 7q21.3 subband among patients with myeloid leukemia and myelodysplastic syndrome
Biochemical and Biophysical Research Communications·2009· 76 cited
Haploinsufficiency and Deficiency of a 7q Gene Titan (Samd9L) Predispose Leukemia Development in Cooperation with Deregulated Expression of a Transcription Factor, Evi1, or a Histone Demethylase, Fbxl10
Blood·2008
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Frequent Co-authors

Hirotaka Matsui(10), Toshiya Inaba(10), Akiko Nagamachi(9), Hiroya Asou(9), Yuko Ozaki(9), Akihiko Yoshimura(9), Yun‐Cai Liu(8), Toshikatsu Hanada(6), Kazuko Saeki(6), Akihiko Yoshimura(5), Yasumasa Minoda(5), Takashi Kobayashi(5), Masanobu Ohishi(4), Hiroyuki Mori(4), Ryuichi Mashima(4), Hiroaki Honda(4), Giichi Takaesu(4), Hiromi Takaki(3), Takahito Sanada(3), Miho Ohsugi(3)