Edward Wai‐Chi Chan

Hong Kong Polytechnic University — Hong Kong

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index9.4kcitations251works4.92yr avg
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Research Topics

Antibiotic Resistance in Bacteria(186), Bacteriophages and microbial interactions(47), Vibrio bacteria research studies(46), Salmonella and Campylobacter epidemiology(43), Pharmaceutical and Antibiotic Environmental Impacts(36)

Publications251 total

Hydrogenase-mediated metabolic functions contribute to formation of bacterial antibiotic tolerance through regulating redox homeostasis and maintaining membrane potential
International Journal of Biological Macromolecules·2025
A COMPREHENSIVE ALGORITHM MEASURING ALPHA-1 ANTITRYPSIN (AAT) SERUM LEVEL, AAT ACTIVITY, AND SEQUENCING SERPINA1 EXONS OR WHOLE GENE TO IMPROVE DIAGNOSIS OF AAT DEFICIENCY
CHEST Journal·2025
IncFIBK/FIIK conjugative iuc3-carrying virulence plasmids of clinical hypervirulent Klebsiella pneumoniae are multi-drug resistant
Microbiological Research·2025· 1 cited
Exposure to the growth promoter tylosin elicits gut microbiota disruption and metabolic imbalance in mouse model
Environment International·2025· 1 citedOpen Access
Profiling the landscape of carbapenem resistance and hypervirulence in Klebsiella pneumoniae: A global epidemiological analysis of the plasmidome
Drug Resistance Updates·2025· 4 cited
Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in <i>Klebsiella pneumoniae</i>
mSystems·2025· 6 citedOpen Access
Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production
PLoS Pathogens·2025· 5 citedOpen Access
Increasing polymyxin resistance in clinical carbapenem-resistant Klebsiella pneumoniae strains in China between 2000 and 2023
Communications Medicine·2025· 4 citedOpen Access
Deciphering comprehensive profiles of pathogenies and resistome of pork using integrating metagenomic and isolation strategies
iMetaOmics.·2025Open Access
Starvation-induced mutagenesis in rhsC and ybfD genes extends bacterial tolerance to various stresses by boosting efflux function
Microbiological Research·2025· 2 citedOpen Access
Simultaneous functional disruption of the iron acquisition system and type VI secretion system results in complete suppression of virulence in Acinetobacter baumannii
Microbiological Research·2025· 6 citedOpen Access
Capsular polysaccharide enables <i>Klebsiella pneumoniae</i> to evade phagocytosis by blocking host-bacteria interactions
mBio·2025· 26 citedOpen Access
DNA repair functions are essential for bacterial stress defense but render antibiotic tolerant sub-populations susceptible to ciprofloxacin and gentamicin upon prolonged treatment
2025Open Access
LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria
Journal of Advanced Research·2025· 8 citedOpen Access
Characterisation of resistance and hypervirulence-encoding genetic elements in foodborne Klebsiella pneumoniae isolates
EMI Animal & Environment·2025Open Access
Antimicrobial effect of sulconazole in combination with glucose/trehalose against carbapenem-resistant hypervirulent Klebsiella pneumoniae persisters
Microbiological Research·2024· 1 cited
Impact of the COVID-19 Pandemic on Existing Disparities in Congenital Syphilis Rates Across Los Angeles County
American Journal of Obstetrics and Gynecology·2024
Lincomycin as a growth-promoting antibiotic induces metabolic and immune dysregulation in animals
The Science of The Total Environment·2024· 6 cited
Overall mutational scanning unveils the essential active residues for the mechanistic action of MCR-1
Microbiological Research·2024· 2 cited
Proton motive force and antibiotic tolerance in bacteria
Microbial Biotechnology·2024· 8 citedOpen Access
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Frequent Co-authors

Sheng Chen(39), Rong Zhang(20), Ning Dong(17), Xuemei Yang(11), Miaomiao Xie(11), Marcus Ho Yin Wong(8), Kaichao Chen(8), Dachuan Lin(6), Ruichao Li(6), Qiaoling Sun(6), Zhiwei Zheng(5), Lingbin Shu(5), Hongwei Zhou(5), Danxia Gu(4), Lianwei Ye(4), Lizhang Liu(3), Miu L. Chin(3), Mamie Hui(3), Qi Xu(3), Qipeng Cheng(3)