Ishan Manandhar

University of Toledo — United States

Medicine · Health Sciences

11h-index1.2kcitations42works2.42yr avg
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Research Topics

Diet and metabolism studies(16), Gut microbiota and health(14), Tryptophan and brain disorders(5), Machine Learning in Healthcare(5), Stress Responses and Cortisol(4)

Publications42 total

The Herbicide Glyphosate Promotes Hypertension via Gut Microbiota-Mediated Mechanisms
2026Open Access
Gut Microbiota-derived Metabolite, Shikimic Acid, is a Novel Regulator of Vascular Tone
Translation The University of Toledo Journal of Medical Sciences·2025Open Access
Sex Hormone Androgen Elevates Blood Pressure Through Gut Microbiota-TMAO Pathway
Hypertension·2025· 2 citedOpen Access
Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat
Hypertension·2025· 3 citedOpen Access
Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome
American Journal of Physiology-Cell Physiology·2025· 3 citedOpen Access
Angiotensin-(1–7) modulates gut-bone marrow axis in diabetes
Biochemical Pharmacology·2025· 2 citedOpen Access
Deletion of Takeda G-protein Coupled Receptor 5 (TGR5) Remodels the Gut Microbiome and Metabolites, Reducing Hypertension in Dahl-Salt-Sensitive Rats
Physiology·2025
Interaction between<i>Akkermansia muciniphila</i>and β-estradiol, and sex-differential blood pressure regulation in spontaneously hypertensive rats
Physiology·2025
Empagliflozin-Metformin in Hypertension Therapy Synergistically Upregulate 3-Hydroxy-3-Methylglutaryl-Coenzyme A Synthase 2 and Acetyl-coenzyme A acyltransferase 1B
Physiology·2025
Farnesoid X Receptor Deletion Protects Against Hypertension, Remodels Gut Microbiome, and Improves Cardiovascular Function
Physiology·2025
The Gut Microbiome is Central to the Mechanistic Adverse Effect of the Environmental Herbicide Glyphosate on Elevating Blood Pressure
Physiology·2025
The Ketone Body β-Hydroxybutyrate Alleviates Metabolic Syndrome Through Epigenetic Chromatin Remodeling
Physiology·2025
Ketone body mediated histone β-hydroxybutyrylation is reno-protective
2024· 1 citedOpen Access
Salt-Responsive Gut Microbiota Induces Sex-Specific Blood Pressure Changes
Circulation Research·2024· 22 citedOpen Access
Abstract P168: The Unholy Link: The Herbicide Glyphosate Contributes to Hypertension, Gut Microbiota Dysbiosis, and Sympathetic Overdrive
Hypertension·2024
Abstract P141: Salt tips the balance of tryptophan metabolism between host and gut microbiota in a sex specific manner
Hypertension·2024
Abstract P166: Genetic Ablation of the Bile Acid Receptor- Takeda G-protein Coupled Receptor 5 (TGR5) Promotes Weight Gain but Lowers Hypertension
Hypertension·2024
Glyphosate, the active ingredient of RoundUp, promotes gut dysbiosis, vascular dysfunction and hypertension
Physiology·2024
Histone β-hydroxybutyrylation-mediated Chromatin Remodeling Upregulates β-oxidation of Fatty Acids and Attenuates Metabolic Syndrome
Physiology·2024· 1 cited
Beyond 16S sequencing for microbiome research: Nanopore sequencing resource at The University of Toledo Microbiome Consortium
Physiology·2024
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Frequent Co-authors

Bina Joe(40), Sachin Aryal(39), Blair Mell(22), Ramakumar Tummala(21), Tao Yang(18), Xue Mei(17), Beng San Yeoh(11), Xi Cheng(10), Pritam Bardhan(10), Matam Vijay–Kumar(10), Piu Saha(9), Ahmad Alimadadi(8), Jasenka Zubcevic(7), Islam Osman(6), Mrunmayee R. Kandalgaonkar(6), Patricia B. Munroe(5), Hong‐Bao Li(5), Sanjana Kumariya(5), Ying Li(4), Saroj Chakraborty(4)