C. Arrowsmith

Medicine · Health Sciences

8h-index4.9kcitations38works0.02yr avg
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Research Topics

Peptidase Inhibition and Analysis(9), Chemical Synthesis and Analysis(8), Histone Deacetylase Inhibitors Research(4), Genomics and Phylogenetic Studies(3), Tuberculosis Research and Epidemiology(3)

Publications38 total

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1
UNC Libraries·2025Open Access
Discovery of a potent and selective fragment-like inhibitor of SPIN1
Abstracts of papers - American Chemical Society·2019
Characterization of Methane Emissions in the Greater Toronto Area Using In-Situ Mobile Measurements
AGU Fall Meeting Abstracts·2018
AirCore profiles of greenhouse and trace gas species for sites within the Total Carbon Column Observing Network (TCCON) and comparisons to models and ground-based Fourier Transform Spectrometer (FTS) retrievals
AGU Fall Meeting Abstracts·2018· 6 cited
Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate
2018
Crystal structure of fragment 3-(1,3-Benzothiazol-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2018
Crystal structure of fragment 2-(Benzo[d]thiazol-2-yl)acetic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2018
Crystal structure of fragment 3-(3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2018
Structure of HDAC6 zinc-finger ubiquitin binding domain soaked with 3,3'-(benzo[1,2-d:5,4-d']bis(thiazole)-2,6-diyl)dipropionic acid
2018
Crystal structure of fragment 3-(quinolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2018
Crystal structure of a low occupancy fragment candidate (5-[(4-Isopropylphenyl)amino]-6-methyl-1,2,4-triazin-3(2H)-one) bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2016
Crystal structure of fragment (3-(5-Chloro-1,3-benzothiazol-2-yl)propanoic acid) bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2016
Crystal structure of fragment (3-[6-Oxo-3-(3-pyridinyl)-1(6H)-pyridazinyl]propanoic acid) bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2016
Crystal structure of a low occupancy fragment candidate (N-(4-Methyl-1,3-thiazol-2-yl)propanamide) bound adjacent to the ubiquitin binding pocket of the HDAC6 zinc-finger domain
2016
NMR structure of UHRF1 Tandem Tudor Domains in a complex with Histone H3 peptide
2010
Brain games for dogs
Medical Entomology and Zoology·2010· 1 cited
Crystal structure of NmrA-like family domain containing protein 1 in complex with NADP and 2-(4-chloro-phenylamino)-nicotinic acid
2009
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis (Genome Research (2008) 18 (729-741))
Genome Research·2008· 1 cited
<i>In situ</i>proteolysis for protein crystallization and structure determination
Acta Crystallographica Section A Foundations of Crystallography·2008Open Access
Identification of novel fragment-based hits for<i>P. berghei</i>orotidine 5′-monophosphate decarboxylase
Acta Crystallographica Section A Foundations of Crystallography·2008Open Access
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Frequent Co-authors

A.M. Edwards(15), Matthieu Schapira(11), C. Bountra(11), Carol Churcher(10), Kay Jagels(10), Sharon Moule(10), Michael A. Quail(10), Sally Whitehead(10), Rachel Harding(10), M. Ravichandran(10), Tracey Chillingworth(9), Vijayaratnam Santhakumar(9), Ester Rabbinowitsch(8), Julian Parkhill(8), Renato Ferreira de Freitas(8), Ann Cronin(7), Karen Mungall(7), Angela Lord(6), Halina Norbertczak(6), Levon Halabelian(6)