Claus U. Pietrzik

Johannes Gutenberg University Mainz — Germany

Medicine · Health Sciences

46h-index8.3kcitations142works3.12yr avg
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Research Topics

Alzheimer's disease research and treatments(74), Cellular transport and secretion(25), Drug Transport and Resistance Mechanisms(21), Cholinesterase and Neurodegenerative Diseases(16), Protease and Inhibitor Mechanisms(12)

Publications142 total

Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation
The FASEB Journal·2025· 1 citedOpen Access
Folic acid-conjugated amphiphilic copolymers for the enhanced delivery of donepezil: synthesis, characterization and blood-brain barrier permeability in a co-culture model
Journal of Biomaterials Science Polymer Edition·2025· 1 cited
HYTANE-Identified Latrophilin-3 Cleavage by Meprin β Leads to Loss of the Interaction Domains
Journal of Proteome Research·2025· 3 citedOpen Access
Targeted approach to determine the impact of cancer-associated protease variants
Science Advances·2025· 1 citedOpen Access
Preparation and characterization of poly(ethylene glycol)- <i>b</i> -poly( <i>tert</i> -butyl methacrylate) micelles as potential nanocarriers for donepezil
Pharmaceutical Development and Technology·2024· 4 cited
Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier
Fluids and Barriers of the CNS·2024· 5 citedOpen Access
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
European Journal of Cell Biology·2024· 7 citedOpen Access
A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes
Cellular and Molecular Life Sciences·2024· 3 citedOpen Access
Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress
Redox Biology·2023· 13 citedOpen Access
Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1
Journal of Biological Chemistry·2023· 2 citedOpen Access
Antibody‐mediated inhibition of tissue‐type plasminogen activator binding to the low‐density lipoprotein receptor‐related protein 1 as a potential beneficial modulator for stroke therapy
Journal of Cellular Biochemistry·2023· 4 citedOpen Access
Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation
Pharmaceutics·2023· 5 citedOpen Access
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Scientific Reports·2023· 12 citedOpen Access
Identifying causal serum protein–cardiometabolic trait relationships using whole genome sequencing
Human Molecular Genetics·2022· 17 citedOpen Access
PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier
Cellular and Molecular Life Sciences·2022· 44 citedOpen Access
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease
Cellular and Molecular Life Sciences·2022· 16 citedOpen Access
The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative β-secretases
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2021· 21 cited
Brain endothelial LRP1 maintains blood–brain barrier integrity
Fluids and Barriers of the CNS·2021· 43 citedOpen Access
Phosphorylation of meprin β controls its cell surface abundance and subsequently diminishes ectodomain shedding
The FASEB Journal·2021· 7 citedOpen Access
Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
International Journal of Molecular Sciences·2021· 13 citedOpen Access
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Frequent Co-authors

Sascha Weggen(22), Edward H. Koo(11), Steffen E. Storck(9), Christoph Becker‐Pauly(9), Elaine Waldron(5), Todd E. Golde(4), Sandra Baches(4), Wladislaw Maier(4), Sébastian Jaeger(4), Thorsten Pflanzner(4), Thorsten Jumpertz(4), Anton Roebroek(4), Eva Czirr(4), Jason L. Eriksen(3), Sarah A. Sagi(3), Sabrina Meister(3), Alessandro Di Spiezio(3), Carsten Korth(3), Christoph Kuhlmann(3), Tamara Jefferson(3)