Brian D. Kelly

University of Kentucky — United States

Materials Science · Physical Sciences

17h-index1.8kcitations37works0.02yr avg
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Research Topics

Dendrimers and Hyperbranched Polymers(17), RNA Interference and Gene Delivery(13), Organometallic Complex Synthesis and Catalysis(7), Synthesis and characterization of novel inorganic/organometallic compounds(5), Synthetic Organic Chemistry Methods(5)

Publications37 total

Abstract A147: A HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imaging
Molecular Cancer Therapeutics·2023
Abstract C167: An SN38 dendrimer nanoparticle, DEP irinotecan (SN38-SPL9111), demonstrates efficacy in mouse models of gastrointestinal cancer and augments anti-tumor effects of immune checkpoint blockade and PARP inhibition
Molecular Cancer Therapeutics·2023· 1 cited
PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence
eLife·2023· 10 citedOpen Access
Author response: PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence
2023Open Access
Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy
Communications Biology·2021· 89 citedOpen Access
Abstract 1715: Anti-cancer activity of a SN-38 nanoparticle, DEP® irinotecan, in human colon cancer xenograft models
Cancer Research·2020· 2 cited
Abstract 1718: Design and optimization of a dendrimer-conjugated dual Bcl-2/Bcl-xL inhibitor, AZD0466, with improved therapeutic index
Cancer Research·2020· 2 cited
Abstract 1716: Anticancer activity of the taxane nanoparticles, DEP® docetaxel and DEP® cabazitaxel
Cancer Research·2020· 14 cited
Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker
Molecular Pharmaceutics·2018· 52 citedOpen Access
Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats
Journal of Pharmaceutical Sciences·2018· 17 cited
Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site
Nanomedicine Nanotechnology Biology and Medicine·2017· 27 citedOpen Access
CCDC 805354: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats
QUT ePrints (Queensland University of Technology)·2015Open Access
Methotrexate-Conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumor-Burdened Lymph Nodes after Intravenous and Subcutaneous Administration in Rats
Molecular Pharmaceutics·2014· 54 cited
Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy
Journal of Controlled Release·2014· 187 cited
Pulmonary Administration of PEGylated Polylysine Dendrimers: Absorption from the Lung versus Retention within the Lung Is Highly Size-Dependent
Molecular Pharmaceutics·2013· 115 cited
ChemInform Abstract: Trimethyl{2‐[(tributylstannyl)methyl]‐2‐propenyl}silane
ChemInform·2012
Doxorubicin-Conjugated PEGylated Dendrimers Show Similar Tumoricidal Activity but Lower Systemic Toxicity When Compared to PEGylated Liposome and Solution Formulations in Mouse and Rat Tumor Models
Molecular Pharmaceutics·2012· 68 cited
Trimethyl{2-[(tributylstannyl)methyl]-2- propenyl}silane
Encyclopedia of Reagents for Organic Synthesis·2011· 1 cited
Synthesis, characterization and crystal structures of the boratranes: 2,10,11-trioxa-6-aza-1-boratricyclo[4.4.4.01,6] tetradecane (tri-n-propanolamine borate), and 3-(4-methoxy)phenoxymethyl-7,10-dimethyl-2,8,9-trioxa-5-aza-1-boratricyclo[3.3.3.01,5]-undecane
Polyhedron·2011· 7 cited
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Frequent Co-authors

David J. Owen(15), Lisa M. Kaminskas(14), Victoria M. McLeod(14), Christopher J. H. Porter(14), Martin G. Banwell(9), Ben J. Boyd(6), Michael I. Bruce(6), Brian W. Skelton(6), Gemma M. Ryan(5), Mark Williamson(5), Allan H. White(5), Michael Giannis(5), Gian Sberna(4), Anne Cargill(4), Graham P. Heery(4), John M. Haynes(3), Elizabeth D. Williams(3), Paul J. Low(3), Carleen Cullinane(3), Dharmini Mehta(3)