Leendert H. J. Looijenga

University Medical Center Utrecht — Netherlands

Medicine · Health Sciences

111h-index70.6kcitations598works2.62yr avg
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Research Topics

Testicular diseases and treatments(320), Sexual Differentiation and Disorders(116), Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities(106), Renal and related cancers(79), Sperm and Testicular Function(70)

Publications562 total

Five years of centralized pediatric oncology care in the Netherlands: Evaluation of diagnosis and treatment of children and adolescents with a malignant extracranial germ cell tumor
EJC Paediatric Oncology·2026Open Access
Safety of laparoscopic oophorectomy in a Dutch national pediatric cancer cohort
F&S Reports·2025Open Access
Identification and validation of liquid biopsy-based methylation biomarkers: a germ cell tumor subtype-specific study
2025Open Access
Risk factors for relapse and guidance for follow-up of extracranial immature teratomas in children: A systematic review
EJC Paediatric Oncology·2025· 1 citedOpen Access
Clinical syndromes linked to biallelic germline variants in MCM8 and MCM9
Human Genetics and Genomics Advances·2025· 1 citedOpen Access
Low-amplitude copy number gains shape cancer through known and novel oncogenes with associated therapeutic vulnerabilities
Nucleic Acids Research·2025· 2 citedOpen Access
Yolk Sac Elements in Tumors Derived from Pluripotent Stem Cells: Borrowing Knowledge from Human Germ Cell Tumors
International Journal of Molecular Sciences·2025· 1 citedOpen Access
Chromosome-specific aberrations, rather than general aneuploidy, may drive mouse embryonic stem cell-derived teratoma metastasis
Stem Cell Research & Therapy·2025· 1 citedOpen Access
Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection
Scientific Reports·2025· 2 citedOpen Access
Depletion of <i>TP53</i> in Human Pluripotent Stem Cells Triggers Malignant‐Like Behavior
Advanced Biology·2025· 1 citedOpen Access
Gonadal function and pathology in 17beta-HSD 3 and 5alpha-reductase deficiency
European Journal of Endocrinology·2025· 3 citedOpen Access
Clinical syndromes linked to biallelic germline variants in <i>MCM8</i> and <i>MCM9</i>
2024· 1 citedOpen Access
Non‐alkylating agents‐induced gonadotoxicity in pre‐pubertal males: Insights on the clinical and pre‐clinical front
Clinical and Translational Science·2024· 1 citedOpen Access
Author Correction: A comprehensive overview of liquid biopsy applications in pediatric solid tumors
npj Precision Oncology·2024· 1 citedOpen Access
Abstract PR005: A toolbox for the use of cfDNA in pediatric cancer patients
Cancer Research·2024
Genome-wide methylation analysis in patients with proximal hypospadias – a pilot study and review of the literature
Epigenetics·2024· 2 citedOpen Access
A comprehensive overview of liquid biopsy applications in pediatric solid tumors
npj Precision Oncology·2024· 18 citedOpen Access
Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q
Stem Cell Reports·2024· 14 citedOpen Access
Alkylating agents‐induced gonadotoxicity in prepubertal males: Insights on the clinical and preclinical front
Clinical and Translational Science·2024· 6 citedOpen Access
Non-Syndromic and Syndromic Defects in Children with Extracranial Germ Cell Tumors: Data of 2610 Children Registered with the German MAKEI 96/MAHO 98 Registry Compared to the General Population
Cancers·2024· 2 citedOpen Access
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Frequent Co-authors

J. Wolter Oosterhuis(26), Ad Gillis(13), Hans Stoop(13), Friedemann Honecker(7), Martine Cools(7), Katja P. Wolffenbuttel(6), Carsten Bokemeyer(6), Michael R. Stratton(5), Remko Hersmus(5), Philip Stephens(4), Raffaella Smith(4), Chris Hunter(4), Graham R. Bignell(4), Helen Davies(4), Jon W. Teague(4), Adam P. Butler(4), Claire Stevens(4), Sarah Edkins(4), Sarah O’Meara(4), Jennifer Cole(4)