I. Holopainen

University of Turku — Finland

Neuroscience · Life Sciences

32h-index3.2kcitations99works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(49), Ion channel regulation and function(18), Aldose Reductase and Taurine(15), Neuroinflammation and Neurodegeneration Mechanisms(11), Epilepsy research and treatment(10)

Publications99 total

Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis
Brain Research·2013· 15 cited
Histamine 1 receptor knock out mice show age-dependent susceptibility to status epilepticus and consequent neuronal damage
Epilepsy Research·2012· 16 cited
Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus
Journal of Neuroinflammation·2011· 51 citedOpen Access
Glutamate signaling in the pathophysiology and therapy of prenatal insults
Pharmacology Biochemistry and Behavior·2011· 20 cited
Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death
Neuropharmacology·2010· 15 cited
Auditory event related potentials as tools to reveal cognitive late effects in childhood cancer patients
Clinical Neurophysiology·2010· 8 cited
Transcriptome Analysis of the Hippocampal CA1 Pyramidal Cell Region after Kainic Acid-Induced Status Epilepticus in Juvenile Rats
PLoS ONE·2010· 52 citedOpen Access
Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice
Epilepsy Research·2010· 25 cited
[Mechanisms of action and clinical use of antiepileptic drugs].
PubMed·2009· 1 cited
Informaation ja tiedon suhteesta omaksumisprosessissa
SHILAP Revista de lepidopterología·2008Open Access
Age‐dependent cyclooxygenase‐2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus
Epilepsia·2008· 17 cited
Placenta Defects and Embryonic Lethality Resulting from Disruption of Mouse Hydroxysteroid (17-β) Dehydrogenase 2 Gene
Molecular Endocrinology·2007· 32 citedOpen Access
Seizures in the developing brain: Cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization
Neurochemistry International·2007· 110 cited
Brain oscillatory EEG event-related desynchronization (ERD) and -sychronization (ERS) responses during an auditory memory task are altered in children with epilepsy
Seizure·2007· 21 citedOpen Access
Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain
Neuroscience·2007· 7 cited
Changes in microtubule‐associated protein‐2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus
International Journal of Developmental Neuroscience·2006· 42 cited
P24 CALPAIN INHIBITORS AND AMPA/KA RECEPTOR ANTAGONISTS INHIBIT KAINIC ACID-INDUCED NEUROFILAMENT DEGRADATION AND NEURONAL DEATH IN ORGANOTYPIC HIPPOCAMPAL CULTURES
Behavioural Pharmacology·2006
Inhaled nitric oxide treatment inhibits neuronal injury after meconium aspiration in piglets
Early Human Development·2006· 15 cited
The calpain inhibitor MDL‐28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid‐treated hippocampal slice cultures
European Journal of Neuroscience·2006· 26 citedOpen Access
AMPA/kainate receptor-mediated up-regulation of GABAA receptor δ subunit mRNA expression in cultured rat cerebellar granule cells is dependent on NMDA receptor activation
Brain Research·2006· 14 cited
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Frequent Co-authors

P. Kontro(8), Francisco R. Lopez‐Picon(8), Karl E.O. Åkerman(7), Hanna B. Laurén(7), M. O. Kristian Enkvist(6), Matti Sillanpää(5), Tiina‐Kaisa Kukko‐Lukjanov(5), Simo S. Oja(5), Pirjo Korpilahti(4), Christina M. Krause(4), Tuula Manner(3), Esa R. Korpi(3), Kimmo A. Michelsen(3), Pertti Panula(3), A. H. Lang(2), Kirsi Juottonen(2), H. Lang(2), Tarja Varho(2), Markku Komu(2), Pirkko Sonninen(2)