Charles E. Egwuagu

National Institutes of Health — United States

Medicine · Health Sciences

46h-index7.0kcitations165works5.82yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Ocular Diseases and Behçet’s Syndrome(51), Cytokine Signaling Pathways and Interactions(51), Systemic Lupus Erythematosus Research(48), interferon and immune responses(40), T-cell and B-cell Immunology(31)

Publications165 total

IL-6/IL-12 superfamily of cytokines and regulatory lymphocytes play critical roles in the etiology and suppression of CNS autoimmune diseases
Frontiers in Immunology·2025· 9 citedOpen Access
Interleukin 35-producing B cells prolong the survival of GVHD mice by secreting exosomes with membrane-bound IL-35 and upregulating PD-1/LAG-3 checkpoint proteins
Theranostics·2025· 3 citedOpen Access
A perspective from the National Eye Institute Extracellular Vesicle Workshop: Gaps, needs, and opportunities for studies of extracellular vesicles in vision research
Journal of Extracellular Vesicles·2024· 7 citedOpen Access
A Camelid-Derived STAT-Specific Nanobody Inhibits Neuroinflammation and Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)
Cells·2024· 4 citedOpen Access
IL-27-containing exosomes secreted by innate B-1a cells suppress and ameliorate uveitis
Frontiers in Immunology·2023· 19 citedOpen Access
Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege
International Journal of Molecular Sciences·2022· 7 citedOpen Access
IL-27–producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases
Proceedings of the National Academy of Sciences·2021· 66 citedOpen Access
STAT3-Specific Single Domain Nanobody Inhibits Expansion of Pathogenic Th17 Responses and Suppresses Uveitis in Mice
Frontiers in Immunology·2021· 14 citedOpen Access
Uveitis: Molecular Pathogenesis and Emerging Therapies
Frontiers in Immunology·2021· 77 citedOpen Access
Deletion of Irf4 in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4+ T Cell Differentiation and Metabolism
International Journal of Molecular Sciences·2021· 7 citedOpen Access
Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis
Methods in molecular biology·2021· 6 citedOpen Access
Identifying Mouse Autoimmune Uveitis from Fundus Photographs Using Deep Learning
Translational Vision Science & Technology·2020· 5 citedOpen Access
STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs
Scientific Reports·2020· 22 citedOpen Access
Interleukin 35 Regulatory B Cells
Journal of Molecular Biology·2020· 50 citedOpen Access
Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis
Frontiers in Immunology·2020· 66 citedOpen Access
Targeted over-expression of S100B in the retina of transgenic mice induced exacerbated experimental autoimmune uveitis
The Journal of Immunology·2019· 1 cited
Intrinsic function of STAT3 in B cells is to promote B cell proliferation and maturation
The Journal of Immunology·2019· 3 cited
Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice
Advances in experimental medicine and biology·2019· 16 citedOpen Access
Production of IL-35 by Bregs is mediated through binding of BATF-IRF-4-IRF-8 complex to <i>il12a</i> and <i>ebi3</i> promoter elements
Journal of Leukocyte Biology·2018· 47 citedOpen Access
Loss of interferon regulatory factor 8 (IRF-8) in B cells promotes the expansion of regulatory B cells (Bregs) and suppresses intraocular autoimmune disease
Investigative Ophthalmology & Visual Science·2018Open Access
page 1 of 9Next →

Frequent Co-authors

Cheng‐Rong Yu(31), Rashid M. Mahdi(14), Igal Gery(9), Yun Sang Lee(6), Jin Kyeong Choi(6), Renxi Wang(5), Ivy M. Dambuza(5), Chang He(5), Ahjoku Amadi‐Obi(4), Lin Sun(4), Samuel Ebong(4), Hyun‐Mee Oh(4), Barbara P. Vistica(4), Chi‐Chao Chan(4), Xuebin Liu(3), Puwat Charukamnoetkanok(3), Mary J. Mattapallil(3), Rachel R Caspi(3), Ana B. Chepelinsky(3), Paul T. Wingfield(2)