M.T. Hilgers

Eli Lilly (United States) — United States

Medicine · Health Sciences

17h-index1.4kcitations35works0.02yr avg
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Research Topics

Antimicrobial Resistance in Staphylococcus(7), RNA and protein synthesis mechanisms(7), Bacterial Genetics and Biotechnology(6), Folate and B Vitamins Research(6), Porphyrin Metabolism and Disorders(6)

Publications35 total

Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
npj Breast Cancer·2022· 1 citedOpen Access
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
npj Breast Cancer·2022· 24 citedOpen Access
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
Figshare·2022Open Access
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacym
OPAL (Open@LaTrobe) (La Trobe University)·2022Open Access
Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
Nature Communications·2020· 37 citedOpen Access
Computational Stabilization of T Cell Receptor Constant Domains
2019
Structure of Methionyl-tRNA Synthetase in complex with N-(1H-benzimidazol-2-ylmethyl)-N'-(2,4-dichlorophenyl)-6-(morpholin-4-yl)-1,3,5-triazine-2,4-diamine
2014· 1 cited
Structure of Methionyl-tRNA Synthetase in complex with 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone
2014
Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines
Journal of Medicinal Chemistry·2014· 71 citedOpen Access
Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design
Journal of Medicinal Chemistry·2013· 49 citedOpen Access
Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines
Bioorganic & Medicinal Chemistry Letters·2011· 59 citedOpen Access
S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines
2011
Elevated Linezolid Resistance in Clinical <i>cfr</i> -Positive <i>Staphylococcus aureus</i> Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3
Antimicrobial Agents and Chemotherapy·2010· 76 citedOpen Access
Structure-Activity Relationships of Diverse Oxazolidinones for Linezolid-Resistant <i>Staphylococcus aureus</i> Strains Possessing the <i>cfr</i> Methyltransferase Gene or Ribosomal Mutations
Antimicrobial Agents and Chemotherapy·2010· 145 citedOpen Access
Mutations in Ribosomal Protein L3 Are Associated with Oxazolidinone Resistance in Staphylococci of Clinical Origin
Antimicrobial Agents and Chemotherapy·2009· 133 citedOpen Access
Novel Ribosomal Mutations in <i>Staphylococcus aureus</i> Strains Identified through Selection with the Oxazolidinones Linezolid and Torezolid (TR-700)
Antimicrobial Agents and Chemotherapy·2009· 202 citedOpen Access
Structural Guided Design of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthase (MetRS)
46th Annual Meeting·2008
Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening
Bioorganic & Medicinal Chemistry Letters·2008· 21 cited
Comparison of the Essential Cellular Functions of the Two <i>murA</i> Genes of <i>Bacillus anthracis</i>
Antimicrobial Agents and Chemotherapy·2008· 17 citedOpen Access
Evaluation of the <i>metS</i> and <i>murB</i> Loci for Antibiotic Discovery Using Targeted Antisense RNA Expression Analysis in <i>Bacillus anthracis</i>
Antimicrobial Agents and Chemotherapy·2007· 19 citedOpen Access
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Frequent Co-authors

Karen Joy Shaw(9), Martha Ludwig(8), J.C. Evans(6), D.P. Huddler(6), Gail Romanchuk(6), Rowena G. Matthews(6), Jeffrey B. Locke(5), G. C. Kedar(5), Mark A. Stidham(5), John M. Finn(4), Duncan E. McRee(4), Vickie Brown‐Driver(4), Severine Gharbi(4), Alfonso Espada(4), Jesus A. Gutierrez(4), Charles T. Rauch(4), Maria Patricia Ganado(4), Carmen Baquero(4), Elisabet Zapatero(4), Jordi Benach(4)