David W. Christianson

Cancer Research Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

83h-index24.1kcitations607works3.02yr avg
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Research Topics

Plant biochemistry and biosynthesis(114), Histone Deacetylase Inhibitors Research(109), Microbial Natural Products and Biosynthesis(87), Peptidase Inhibition and Analysis(78), Enzyme function and inhibition(65)

Publications607 total

Covalent Binding of the Boronic Acid-Based Inhibitor GSK4394835A to Phosphodiesterase 3B, a Drug Target for Cardiovascular Disease
Journal of Medicinal Chemistry·2025Open Access
Structure and Mechanism of Avermitilol Synthase, a Sesquiterpene Cyclase That Generates a Highly Strained 6–6–3 Tricyclic Alcohol
Biochemistry·2025Open Access
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
2025Open Access
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
2025Open Access
Author response: Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
2025Open Access
Covalent Binding of Boronic Acid-Based Inhibitor GSK4394835A to Phosphodiesterase 3B, a Drug Target for Cardiovascular Disease
2025Open Access
Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene Synthase
Biochemistry·2025Open Access
A Giant Step for Terpene Biosynthesis
Biochemistry·2025
Structure and Mechanism of Avermitilol Synthase, a Sesquiterpene Cyclase that Generates a Highly Strained 6-6-3 Tricyclic Alcohol
2025Open Access
Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene Synthase
2025Open Access
Cryo-EM Structure of the Class II Cyclase Domain in the Bifunctional Copalyl Diphosphate Synthase from Penicillium verruculosum
2025
Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase–phosphatase
Proceedings of the National Academy of Sciences·2025· 4 citedOpen Access
Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization
Nature Communications·2025· 3 citedOpen Access
Abstract 1601 Structure and Mechanism of a Bifunctional Terpene Cyclase-Phosphatase
Journal of Biological Chemistry·2025Open Access
DREDge: robust motion correction for high-density extracellular recordings across species
Nature Methods·2025· 14 cited
Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate Is Subject to Redox Modulation
Journal of the American Chemical Society·2025· 2 citedOpen Access
Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers <b>DS-103</b> as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties
Journal of Medicinal Chemistry·2025· 11 citedOpen Access
Crystal Structure and Catalytic Mechanism of Drimenol Synthase, a Bifunctional Terpene Cyclase-Phosphatase
2025· 1 citedOpen Access
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
2025· 4 citedOpen Access
Mechanism-Based Inhibition of Histone Deacetylase 6 by a Selenocyanate is Subject to Redox Modulation
2025Open Access
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Frequent Co-authors

Carol A. Fierke(7), David E. Cane(6), Lakshmi Santhanam(4), Daniel Nyhan(4), Dan E. Berkowitz(4), Satish K. Nair(4), Kathryn Cole(3), Yang Hai(3), J. David Cox(3), Robert M. Coates(3), Douglas A. Whittington(3), Daniel Dowling(3), Sungwoo Ryoo(3), Artin A. Shoukas(3), Luigi Di Costanzo(3), Travis Stams(3), Julie A. Aaron(3), Masashige Bando(2), Dinah Clark(2), Christophe Decroos(2)