Jos Grimbergen

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index3.4kcitations60works0.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(20), Blood Coagulation and Thrombosis Mechanisms(17), Blood properties and coagulation(14), Virus-based gene therapy research(11), Cell Adhesion Molecules Research(6)

Publications60 total

Interplay of fibrinogen αEC globular domains and factor XIIIa cross-linking dictates the extensibility and strain stiffening of fibrin networks
Journal of Thrombosis and Haemostasis·2023· 6 citedOpen Access
Fibrinogen γ′ promotes host survival during Staphylococcus aureus septicemia in mice
Journal of Thrombosis and Haemostasis·2023· 12 citedOpen Access
Hydrodynamic characterization of recombinant human fibrinogen species
UNC Libraries·2020Open Access
Recombinant fibrinogen reveals the differential roles of α‐ and γ‐chain cross‐linking and molecular heterogeneity in fibrin clot strain‐stiffening
Journal of Thrombosis and Haemostasis·2017· 31 citedOpen Access
Fibrinogen reduction and coagulation in cardiac surgery
Blood Coagulation & Fibrinolysis·2015· 15 cited
Unraveling the Link between Nonlinear Mechanics, Microstructure, and Molecular Packing of Fibrin
Biophysical Journal·2015Open Access
Factor XIII stiffens fibrin clots by causing fiber compaction
Journal of Thrombosis and Haemostasis·2014· 102 citedOpen Access
Hydrodynamic characterization of recombinant human fibrinogen species
Thrombosis Research·2013· 19 citedOpen Access
A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
Cardiovascular Research·2010· 18 citedOpen Access
In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor
Journal of Vascular Surgery·2009· 18 citedOpen Access
Prolonged <i>In Vivo</i> Gene Silencing by Electroporation-Mediated Plasmid Delivery of Small Interfering RNA
Human Gene Therapy·2007· 23 cited
Inhibition of Complement Component C3 Reduces Vein Graft Atherosclerosis in Apolipoprotein E3–Leiden Transgenic Mice
Circulation·2006· 52 citedOpen Access
The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice
Atherosclerosis·2006· 37 cited
Generation of a novel replication-incompetent adenoviral vector derived from human adenovirus type 49: manufacture on PER.C6 cells, tropism and immunogenicity
Journal of General Virology·2006· 90 cited
Anti–MCP-1 Gene Therapy Inhibits Vascular Smooth Muscle Cells Proliferation and Attenuates Vein Graft Thickening Both In Vitro and In Vivo
Arteriosclerosis Thrombosis and Vascular Biology·2006· 125 citedOpen Access
596. A Novel Replication Incompetent Human Subgroup D Adenoviral Vector Based on Type 49: Manufacture on PER.C6®, Cell Tropism and Immunogenicity
Molecular Therapy·2006Open Access
Involvement of furin-like proprotein convertases in the arterial response to injury
Cardiovascular Research·2005· 29 citedOpen Access
Novel Replication-Incompetent Vector Derived from Adenovirus Type 11 (Ad11) for Vaccination and Gene Therapy: Low Seroprevalence and Non-Cross-Reactivity with Ad5
Journal of Virology·2004· 143 citedOpen Access
Involvement of Membrane-Type Matrix Metalloproteinases (MT-MMPs) in Capillary Tube Formation by Human Endometrial Microvascular Endothelial Cells: Role of MT3-MMP
The Journal of Clinical Endocrinology & Metabolism·2004· 74 cited
Vascular Endothelial Growth Factor Overexpression in Ischemic Skeletal Muscle Enhances Myoglobin Expression In Vivo
Circulation Research·2004· 69 cited
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Frequent Co-authors

Paul H.A. Quax(31), Victor W.M. van Hinsbergh(12), Margreet R. de Vries(12), J. Koopman(10), J. Hajo van Bockel(8), Menzo Havenga(7), J.H. Lardenoye(7), Martine L.M. Lamfers(7), Ronald Vogels(5), Angelique A. C. Lemckert(5), Pieter Koolwijk(5), L.G.M. Huisman(5), D. Eefting(5), A. Bout(4), Vincent van Weel(4), F. Haverkate(4), Susan T. Lord(4), M Aalders(4), Jaap Goudsmit(3), Hans Pannekoek(3)