Hans van Dam

Leiden University Medical Center — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index7.3kcitations97works0.02yr avg
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Research Topics

TGF-β signaling in diseases(19), Ubiquitin and proteasome pathways(17), Virus-based gene therapy research(15), Viral Infectious Diseases and Gene Expression in Insects(12), Cancer-related gene regulation(9)

Publications97 total

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism
Proceedings of the National Academy of Sciences·2023· 23 citedOpen Access
Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2
ACS Chemical Biology·2023· 7 citedOpen Access
USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins
2023· 3 citedOpen Access
A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity
Angewandte Chemie International Edition·2023· 4 citedOpen Access
A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity
Angewandte Chemie·2023Open Access
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling
Nature Communications·2022· 149 citedOpen Access
TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness
Oncogene·2020· 91 citedOpen Access
JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
Cells·2019· 18 citedOpen Access
Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression
Breast Cancer Research·2019· 166 citedOpen Access
VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation
Journal of Molecular Cell Biology·2019· 16 citedOpen Access
Additional file 1: of Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression
Figshare·2019Open Access
De pil van Drion: een voetafdruk in de beschaving
Filosofie & Praktijk·2019
FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
Cell Host & Microbe·2018· 48 citedOpen Access
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ
Molecular Cell·2018· 200 citedOpen Access
Inflammation induces endothelial‐to‐mesenchymal transition and promotes vascular calcification through downregulation of BMPR2
The Journal of Pathology·2018· 193 citedOpen Access
Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?
Oncogene·2018· 158 cited
Tumor-derived exosomes antagonize innate antiviral immunity
Nature Immunology·2018· 195 cited
Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
Nature Communications·2017· 180 citedOpen Access
Regulation of AP-1 Activity by Adenovirus E1A: Dissection of Dimers Containing Jun, Fos, and ATF/CREB Members
2017
JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion
Nucleic Acids Research·2017· 109 citedOpen Access
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Frequent Co-authors

Long Zhang(18), Peter ten Dijke(18), Fangfang Zhou(15), Ke Jin(8), Peter Herrlich(7), Feng Xie(7), Peter Angel(5), Marc Castellazzi(5), Bing Yang(5), Anders Sundqvist(5), Jin Jin(4), Zhengkui Zhang(4), Huizhe Huang(4), Theo van Laar(4), A. Zantema(3), Zhengkui Zhang(3), Min Zheng(3), Tong Dai(3), Pengfei Fang(3), Junling Jia(3)