Anna S. Sedukhina

St. Marianna University School of Medicine — Japan

Medicine · Health Sciences

6h-index276citations16works2.02yr avg
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Research Topics

PARP inhibition in cancer therapy(7), DNA Repair Mechanisms(4), Ovarian cancer diagnosis and treatment(3), Prostate Cancer Treatment and Research(2), CRISPR and Genetic Engineering(2)

Publications16 total

EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration
Frontiers in Cell and Developmental Biology·2025Open Access
PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition
Scientific Reports·2024· 6 citedOpen Access
PLK1 overexpression suppresses homologous recombination and confers cellular sensitivity to PARP inhibition
2024Open Access
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer
2021
A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer
Scientific Reports·2021· 7 citedOpen Access
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer
EMBO Molecular Medicine·2021· 55 citedOpen Access
Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51
2020Open Access
NF‐kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol
FEBS Open Bio·2020· 6 citedOpen Access
A bioinformatics-to-clinic sequential approach to analysis of prostate cancer biomarkers using TCGA datasets and clinical samples: a new method for precision oncology?
Oncotarget·2017· 6 citedOpen Access
BRCA1とPARP inhibitor: LSD1過剰発現とPARP inhibitor感受性、NF-kBと耐性機序
日本分子生物学会/日本生化学会·2015
LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition
PLoS ONE·2015· 87 citedOpen Access
NF-κB signaling mediates acquired resistance after PARP inhibition
Oncotarget·2015· 43 citedOpen Access
Proteomic Analysis Reveals the Association between the Rho-GDI Signaling Pathway and Kidney Injury in Spontaneously Hypertensive and Hyperlipidemic Rats
Journal of St Marianna University·2015Open Access
[Oncogene and tumor suppressor gene].
PubMed·2012
A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair
Current Biology·2012· 66 citedOpen Access
[BRCA1 and DNA damage response].
PubMed·2012

Frequent Co-authors

Ko Sato(11), Anand D. Jeyasekharan(6), Kimino Minagawa(6), Ichiro Maeda(5), Tomohiko Ohta(5), Juan A. Bernal(5), Sookhee Pae(4), Toshio Kumai(4), Kazuo Yudo(4), Eri Sato(4), Ayako Yamaura(4), Marta Roche-Molina(3), Michał Marek Hoppe(3), Patrick Jaynes(3), Joanna D. Wardyn(3), Tuan Zea Tan(3), Stefanus Lie(3), Diana GZ Lim(3), Sherlly Lim(3), Anthony N. Karnezis(3)