Oleksandr Gakh

Mayo Clinic in Arizona — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.2kcitations49works0.82yr avg
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Research Topics

Mitochondrial Function and Pathology(28), Genetic Neurodegenerative Diseases(28), Fungal and yeast genetics research(10), Enzyme Structure and Function(7), Metalloenzymes and iron-sulfur proteins(7)

Publications47 total

Fourier transform infrared spectroscopy detects distinct TAR DNA-binding protein 43 signatures in frontotemporal lobar degeneration
Frontiers in Neuroscience·2025Open Access
Mitochondrial intermediate peptidase
Handbook of Proteolytic Enzymes·2025
Infrared spectral profiling of demyelinating activity in multiple sclerosis brain tissue
Acta Neuropathologica Communications·2024· 3 citedOpen Access
Biomolecular alterations detected in multiple sclerosis skin fibroblasts using Fourier transform infrared spectroscopy
Frontiers in Cellular Neuroscience·2023· 7 citedOpen Access
Correction for: Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis
Aging·2021Open Access
Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis
Aging·2020· 14 citedOpen Access
SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY
PLoS ONE·2017· 2 citedOpen Access
Zinc and the iron donor frataxin regulate oligomerization of the scaffold protein to form new Fe–S cluster assembly centers
Metallomics·2017· 9 citedOpen Access
Defining the Architecture of the Core Machinery for the Assembly of Fe–S Clusters in Human Mitochondria
Methods in enzymology on CD-ROM/Methods in enzymology·2017· 2 cited
Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery
Journal of Biological Chemistry·2016· 27 citedOpen Access
Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery: the Complex Formed by the Iron Donor, the Sulfur Donor, and the Scaffold
2016
The Structure of the Complex between Yeast Frataxin and Ferrochelatase
Journal of Biological Chemistry·2016· 25 citedOpen Access
Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery
Journal of Biological Chemistry·2016· 20 citedOpen Access
<i>PMPCA</i>mutations cause abnormal mitochondrial protein processing in patients with non-progressive cerebellar ataxia
Brain·2015· 75 citedOpen Access
High-Throughput Immunoassay for the Biochemical Diagnosis of Friedreich Ataxia in Dried Blood Spots and Whole Blood
Clinical Chemistry·2013· 11 citedOpen Access
The Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in Oligomerization
Journal of Biological Chemistry·2013· 24 citedOpen Access
The Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in
2013
Missense Mutations Linked to Friedreich Ataxia Have Different but Synergistic Effects on Mitochondrial Frataxin Isoforms
Journal of Biological Chemistry·2012· 28 citedOpen Access
Mitochondrial Intermediate Peptidase
Handbook of Proteolytic Enzymes·2012· 2 cited
Oligomerization Propensity and Flexibility of Yeast Frataxin Studied by X-ray Crystallography and Small-Angle X-ray Scattering
Journal of Molecular Biology·2011· 27 cited
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Frequent Co-authors

Grazia Isaya(37), Salam Al‐Karadaghi(13), Douglas Y. Smith(8), Wasantha Ranatunga(6), Christopher A. G. Söderberg(6), Sungjo Park(5), Jordan Wilkins(5), Claudia F. Lucchinetti(5), Glória C. Ferreira(4), Heather A. O’Neill(4), Jiří Adamec(4), Jiřı́ Janata(4), S. S. Rajan(4), James R. Thompson(4), T. Karlberg(3), Ulrika Schagerlöf(3), Martin Lindahl(3), Alexander V. Shkumatov(3), Dmitri I. Svergun(3), Eva-Christina Ahlgren(3)