Steven Whitebread

Novartis (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

41h-index8.0kcitations89works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(31), Computational Drug Discovery Methods(19), Renin-Angiotensin System Studies(17), Neuropeptides and Animal Physiology(12), Pharmacogenetics and Drug Metabolism(11)

Publications89 total

The activities of drug inactive ingredients on biological targets
Science·2020· 86 citedOpen Access
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228
Bioorganic & Medicinal Chemistry Letters·2018· 58 citedOpen Access
Inhibition of Bile Salt Export Pump (BSEP) in Relation to Systemic Exposure: A Risk Factor for Drug Induced Liver Injury (DILI)
Journal of Pharmacological and Toxicological Methods·2017· 2 cited
Adverse Drug Reactions of Marketed Drugs: How Can We Use Them to Our Advantage?
Journal of Pharmacological and Toxicological Methods·2017
Learning from approved kinase inhibitors to better inform on the safety risks of specific kinases
Toxicology Letters·2017
Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets
eLife·2017· 50 citedOpen Access
Author response: Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets
2017· 1 citedOpen Access
Predictive Toxicology: Latest Scientific Developments and Their Application in Safety Assessment
Elsevier eBooks·2016· 3 cited
Secondary pharmacology: screening and interpretation of off-target activities – focus on translation
Drug Discovery Today·2016· 58 cited
Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation
Current Topics in Medicinal Chemistry·2016· 25 cited
Targets Associated with Drug‐Related Suicidal Ideation and Behavior
Methods and principles in medicinal chemistry·2015· 2 cited
Translational Value of Preclinical Safety Assessment: System Organ Class (SOC) Representation of Off‐Targets
Methods and principles in medicinal chemistry·2015· 1 cited
Side Effects of Marketed Drugs: The Utility and Pitfalls of Pharmacovigilance
Methods and principles in medicinal chemistry·2015· 2 cited
The AT2 Receptor
Elsevier eBooks·2015
Contributors
Elsevier eBooks·2015
A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products
ACS Chemical Biology·2014· 44 cited
Matched Molecular Pair Analysis: Significance and the Impact of Experimental Uncertainty
Journal of Medicinal Chemistry·2014· 75 cited
Translation of off-target effects: prediction of ADRs by integrated experimental and computational approach
Toxicology Research·2014· 14 cited
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
Nature Reviews Drug Discovery·2012· 729 cited
Large-scale prediction and testing of drug activity on side-effect targets
Nature·2012· 879 citedOpen Access
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Frequent Co-authors

Marc de Gasparo(20), László Urbán(15), Leoluca Criscione(10), Jacques Hamon(10), Khalil Azzaoui(7), Alain Stricker‐Krongrad(6), Karl G. Hofbauer(5), Jeremy L. Jenkins(5), Andreas Bender(5), L. Brunner(5), Christophe Gerald(4), Andrea O. Schaffhauser(4), B. Kamber(4), Josef Scheiber(4), Meir Glick(4), Peter Bühlmayer(4), Frédéric Cumin(4), Mary W. Walker(3), Eugen Lounkine(3), Д. А. Михайлов(3)