Graeme Semple

Beacon Clinical Research — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index2.8kcitations103works4.52yr avg
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Research Topics

Receptor Mechanisms and Signaling(32), Neuropeptides and Animal Physiology(21), Diabetes Treatment and Management(12), Pharmacological Receptor Mechanisms and Effects(10), Chemical Synthesis and Analysis(9)

Publications103 total

Hydroxycarboxylic acid receptors in GtoPdb v.2025.3
IUPHAR/BPS Guide to Pharmacology CITE·2025Open Access
Diazepine Agonists of the 5-HT<sub>2C</sub> Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352)
Journal of Medicinal Chemistry·2025· 9 citedOpen Access
Hydroxycarboxylic acid receptors in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE·2023Open Access
Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure
Results in Chemistry·2022Open Access
Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT2C receptor
Bioorganic & Medicinal Chemistry Letters·2021· 1 citedOpen Access
Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays
Bioorganic & Medicinal Chemistry Letters·2019· 5 citedOpen Access
Hydroxycarboxylic acid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
IUPHAR/BPS Guide to Pharmacology CITE·2019· 1 citedOpen Access
Angiotensin (1–7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor
Cellular Signalling·2018· 56 cited
Asymmetric syntheses of (R)-4-halo-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines, important 5-HT2C agonist precursors
Tetrahedron Letters·2018· 7 cited
Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor
Pharmacological Research·2018· 53 cited
Discovery of APD371: Identification of a Highly Potent and Selective CB<sub>2</sub>Agonist for the Treatment of Chronic Pain
ACS Medicinal Chemistry Letters·2017· 40 citedOpen Access
Discovery of 2-(((1<i>r</i>,4<i>r</i>)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Journal of Medicinal Chemistry·2017· 17 citedOpen Access
Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor
Bioorganic & Medicinal Chemistry Letters·2016· 8 citedOpen Access
Complementary asymmetric routes to fused tricyclic (R)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinolines and (R)-1,2,3,4,5,5a,6,7-octahydro-[1,4]diazepino[1,2-a]quinolines
Tetrahedron Letters·2016· 5 cited
An Efficient Scale-Up Process for the Preparation of the APD334 Precursor 4-Chloromethyl-1-cyclopentyl-2-(trifluoromethyl)benzene
Organic Process Research & Development·2015· 11 cited
Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series
Bioorganic & Medicinal Chemistry Letters·2015· 13 citedOpen Access
Discovery of a new series of potent prostacyclin receptor agonists with in vivo activity in rat
Bioorganic & Medicinal Chemistry Letters·2015· 6 citedOpen Access
Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists
Bioorganic & Medicinal Chemistry Letters·2014· 9 citedOpen Access
(7-Benzyloxy-2,3-dihydro-<i>1H</i>-pyrrolo[1,2-<i>a</i>]indol-1-yl)acetic Acids as S1P<sub>1</sub> Functional Antagonists
ACS Medicinal Chemistry Letters·2014· 16 citedOpen Access
Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor
ACS Medicinal Chemistry Letters·2014· 70 citedOpen Access
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Frequent Co-authors

Carleton R. Sage(13), Daniel T. Connolly(12), Jeremy G. Richman(11), Ruoping Chen(10), Robert M. Jones(9), David J. Unett(9), Andrew J. Grottick(9), Philip J. Skinner(9), Tawfik Gharbaoui(9), Dominic P. Behan(8), Michael Morgan(8), P. Douglas Boatman(8), Martin C. Cherrier(8), Peter J. Webb(8), Ibragim Gaidarov(7), Albert Ren(6), Thuy-Anh Tran(6), Young‐Jun Shin(6), Jae‐Kyu Jung(6), Susan Y. Tamura(6)